Following various articles in literature which have appeared in the last 3 years regarding the neurotoxicity of desferrioxamine B we studied, from the auditory functionality point of view, 95 patients affected with transfusion-dependent thalassemic syndromes, under regular chelation treatment with desferrioxamine B. Our results lead us to conclude that at standard doses, between 40 and 60 mg/Kg/day, desferrioxamine B does not demonstrate a neurotoxicity enough to cause an organic deficit in the auditory sphere, while maintaining therapeutic efficacy.

Gaini, R., Moretti, E., Boffa, C., Terzoli, S., Carnelli, V. (1988). Audiologic evaluation of patients with thalassemic syndromes treated with desferrioxamine B. PEDIATRIA MEDICA E CHIRURGICA, 10(5), 503-504.

Audiologic evaluation of patients with thalassemic syndromes treated with desferrioxamine B

GAINI, RENATO MARIA;
1988

Abstract

Following various articles in literature which have appeared in the last 3 years regarding the neurotoxicity of desferrioxamine B we studied, from the auditory functionality point of view, 95 patients affected with transfusion-dependent thalassemic syndromes, under regular chelation treatment with desferrioxamine B. Our results lead us to conclude that at standard doses, between 40 and 60 mg/Kg/day, desferrioxamine B does not demonstrate a neurotoxicity enough to cause an organic deficit in the auditory sphere, while maintaining therapeutic efficacy.
Articolo in rivista - Articolo scientifico
Male; Adolescent; Deferoxamine; Audiometry; Female; Child, Preschool; Child; Thalassemia; Adult; Acoustic Impedance Tests; Humans; Hearing Loss, Sensorineural
Italian
1988
10
5
503
504
none
Gaini, R., Moretti, E., Boffa, C., Terzoli, S., Carnelli, V. (1988). Audiologic evaluation of patients with thalassemic syndromes treated with desferrioxamine B. PEDIATRIA MEDICA E CHIRURGICA, 10(5), 503-504.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/17287
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