Objectives: To explore whether facial emotion recognition (FER), impaired in both schizophrenia and alcohol and substance use disorders (AUDs/SUDs), is additionally compromised among comorbid subjects, also considering the role of catechol‐O‐methyltransferase (COMT) Val158Met. Methods: We conducted a cross‐sectional study, randomly recruiting 67 subjects with a DSM‐IV‐TR diagnosis of schizophrenia, and rigorously assessing AUDs/SUDs and COMT Val158Met polymorphism. FER was assessed using the Ekman 60 Faces Test‐ EK‐60F. Results: As a whole, the sample scored significantly lower than normative data on EK‐60F. However, subjects with comorbid AUDs/SUDs did not perform worse on EK‐60F than those without, who had a better performance on EK‐60F if they carried the COMT Val/Met variant. Conclusions: This study is the first to date examining the impact of AUDs/SUDs and COMT variants on FER in an epidemiologically representative sample of subjects with schizophrenia. Our findings do not suggest an additional impairment from comorbid AUDs/SUDs on FER among subjects with schizophrenia, whilst COMT Val158Met, though based on a limited sample, might have a role just among those without AUDs/SUDs. Based on our results, additional research is needed also exploring differential roles of various substances.

Carra', G., Nicolini, G., Lax, A., Bartoli, F., Castellano, F., Chiorazzi, A., et al. (2017). Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met. HUMAN PSYCHOPHARMACOLOGY, 32(6) [10.1002/hup.2630].

Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met

CARRA', GIUSEPPE
Primo
;
NICOLINI, GABRIELLA
Secondo
;
LAX, ANNAMARIA;BARTOLI, FRANCESCO;CASTELLANO, FILIPPO;CHIORAZZI, ALESSIA;GAMBA, GIULIA;BAVA, MATTIA;CROCAMO, CRISTINA
Penultimo
;
PAPAGNO, COSTANZA
Ultimo
2017

Abstract

Objectives: To explore whether facial emotion recognition (FER), impaired in both schizophrenia and alcohol and substance use disorders (AUDs/SUDs), is additionally compromised among comorbid subjects, also considering the role of catechol‐O‐methyltransferase (COMT) Val158Met. Methods: We conducted a cross‐sectional study, randomly recruiting 67 subjects with a DSM‐IV‐TR diagnosis of schizophrenia, and rigorously assessing AUDs/SUDs and COMT Val158Met polymorphism. FER was assessed using the Ekman 60 Faces Test‐ EK‐60F. Results: As a whole, the sample scored significantly lower than normative data on EK‐60F. However, subjects with comorbid AUDs/SUDs did not perform worse on EK‐60F than those without, who had a better performance on EK‐60F if they carried the COMT Val/Met variant. Conclusions: This study is the first to date examining the impact of AUDs/SUDs and COMT variants on FER in an epidemiologically representative sample of subjects with schizophrenia. Our findings do not suggest an additional impairment from comorbid AUDs/SUDs on FER among subjects with schizophrenia, whilst COMT Val158Met, though based on a limited sample, might have a role just among those without AUDs/SUDs. Based on our results, additional research is needed also exploring differential roles of various substances.
Articolo in rivista - Articolo scientifico
alcohol dependence; dopamine; genetic polymorphism; neuropsychology; schizophrenia; substance dependence
English
Carra', G., Nicolini, G., Lax, A., Bartoli, F., Castellano, F., Chiorazzi, A., et al. (2017). Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met. HUMAN PSYCHOPHARMACOLOGY, 32(6) [10.1002/hup.2630].
Carra', G; Nicolini, G; Lax, A; Bartoli, F; Castellano, F; Chiorazzi, A; Gamba, G; Bava, M; Crocamo, C; Papagno, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/170210
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