Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.

Moresco, R., Govoni, S., Battaini, F., Trivulzio, S., Trabucchi, M. (1990). Omegaconotoxin binding decreases in aged rat brain. NEUROBIOLOGY OF AGING, 11(4), 433-436 [10.1016/0197-4580(90)90010-W].

Omegaconotoxin binding decreases in aged rat brain

MORESCO, ROSA MARIA;
1990

Abstract

Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.
Articolo in rivista - Articolo scientifico
Omegaconotoxin, calcium
English
1990
11
4
433
436
none
Moresco, R., Govoni, S., Battaini, F., Trivulzio, S., Trabucchi, M. (1990). Omegaconotoxin binding decreases in aged rat brain. NEUROBIOLOGY OF AGING, 11(4), 433-436 [10.1016/0197-4580(90)90010-W].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/16998
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