In implementing published procedures for the incorporation of [C-11]carbon dioxide on the immobilized Grignard reagents for the radiosynthesis of [C-11]acyl chlorides, several modifications on a commercial PET tracer synthesizer module for C-11-methylations were made to obtain reliable and reproducible production processes for routine clinical applications. High yields of [carbonyl-C-11]WAY-100635 and [C-11]zofenoprilat were obtained via C-11-carboxylation using [carbonyl-C-11]cyclohexanecarbonyl chloride and 2-methyl-[1-C-11]acryloyl chloride prepared with the modified module. (C) 2002 Elsevier Science Ltd. All rights reserved.
Matarrese, M., Sudati, F., Soloviev, D., Todde, S., Turolla, E., Kienle, M., et al. (2002). Automation of [C-11]acyl chloride syntheses using commercially available C-11-modules. APPLIED RADIATION AND ISOTOPES, 57(5), 675-679 [10.1016/S0969-8043(02)00182-3].
Automation of [C-11]acyl chloride syntheses using commercially available C-11-modules
TODDE, SERGIO CAMILLO;KIENLE, MARZIA DONATELLA;FAZIO, FERRUCCIO
2002
Abstract
In implementing published procedures for the incorporation of [C-11]carbon dioxide on the immobilized Grignard reagents for the radiosynthesis of [C-11]acyl chlorides, several modifications on a commercial PET tracer synthesizer module for C-11-methylations were made to obtain reliable and reproducible production processes for routine clinical applications. High yields of [carbonyl-C-11]WAY-100635 and [C-11]zofenoprilat were obtained via C-11-carboxylation using [carbonyl-C-11]cyclohexanecarbonyl chloride and 2-methyl-[1-C-11]acryloyl chloride prepared with the modified module. (C) 2002 Elsevier Science Ltd. All rights reserved.
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