The fully unprotected α-C-glycosyl analogue of N-acetylgalactosamine 9 was conjugated by a non-natural oxime bond to the segment peptides 328-340OVA and 327-339OVA, affording neoglycopeptides 1-2 and 3, having one or two sugar units, respectively. The three neoglycopeptides were tested in vitro in an antigen presentation assay as antitumor vaccines. Neoglycopeptides 1-3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope. © 2002 Elsevier Science Ltd. All rights reserved.
Cipolla, L.F., Rescigno, M., Leone, A., Peri, F., La Ferla, B., & Nicotra, F. (2002). Novel Tn antigen containing neoglycopeptides: synthesis and evaluation as antitumour vaccines. BIOORGANIC & MEDICINAL CHEMISTRY, 10, 1639-1646.
Citazione: | Cipolla, L.F., Rescigno, M., Leone, A., Peri, F., La Ferla, B., & Nicotra, F. (2002). Novel Tn antigen containing neoglycopeptides: synthesis and evaluation as antitumour vaccines. BIOORGANIC & MEDICINAL CHEMISTRY, 10, 1639-1646. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Titolo: | Novel Tn antigen containing neoglycopeptides: synthesis and evaluation as antitumour vaccines |
Autori: | Cipolla, LF; Rescigno, M; Leone, A; Peri, F; La Ferla, B; Nicotra, F |
Autori: | |
Data di pubblicazione: | 2002 |
Lingua: | English |
Rivista: | BIOORGANIC & MEDICINAL CHEMISTRY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0968-0896(01)00433-3 |
Appare nelle tipologie: | 01 - Articolo su rivista |