Despite of the development of advanced segmentation techniques, achieving accurate and reproducible gross tumor volume (GTV) segmentation results is still an important challenge in neuro-radiosurgery. Nowadays, magnetic resonance imaging (MRI) is the most prominent modality in radiation therapy for soft-tissue anatomical districts. Gamma Knife stereotactic neuro-radiosurgery is a minimally invasive technology for dealing with inaccessible or insufficiently treated tumors with traditional surgery or radiotherapy. During a treatment planning phase, the GTV is generally contoured by experienced neurosurgeons and radiation oncologists using fully manual segmentation procedures on MR images. Unfortunately, this operative methodology is definitely time-expensive and operator-dependent. Delineation result repeatability, in terms of both intra- and inter-operator reliability, can be achieved only by using computer-assisted approaches. In this paper a novel semi-automatic seeded image segmentation method, based on a cellular automata model, for MRI brain cancer detection and delineation is proposed. This approach, called GTVcut, employs an adaptive seed selection strategy and helps to segment the GTV, by identifying the target volume to be treated using the Gamma Knife device. The accuracy of GTVcut was evaluated on a dataset composed of 32 brain cancers, using both spatial overlap-based and distance-based metrics. The achieved experimental results are very reproducible, showing the effectiveness and the clinical feasibility of the proposed approach.

Rundo, L., Militello, C., Russo, G., Vitabile, S., Gilardi, M., Mauri, G. (2018). GTVcut for neuro-radiosurgery treatment planning: an MRI brain cancer seeded image segmentation method based on a cellular automata model. NATURAL COMPUTING, 17(3), 521-536 [10.1007/s11047-017-9636-z].

GTVcut for neuro-radiosurgery treatment planning: an MRI brain cancer seeded image segmentation method based on a cellular automata model

RUNDO, LEONARDO
Primo
;
GILARDI, MARIA CARLA
Penultimo
;
MAURI, GIANCARLO
Ultimo
2018

Abstract

Despite of the development of advanced segmentation techniques, achieving accurate and reproducible gross tumor volume (GTV) segmentation results is still an important challenge in neuro-radiosurgery. Nowadays, magnetic resonance imaging (MRI) is the most prominent modality in radiation therapy for soft-tissue anatomical districts. Gamma Knife stereotactic neuro-radiosurgery is a minimally invasive technology for dealing with inaccessible or insufficiently treated tumors with traditional surgery or radiotherapy. During a treatment planning phase, the GTV is generally contoured by experienced neurosurgeons and radiation oncologists using fully manual segmentation procedures on MR images. Unfortunately, this operative methodology is definitely time-expensive and operator-dependent. Delineation result repeatability, in terms of both intra- and inter-operator reliability, can be achieved only by using computer-assisted approaches. In this paper a novel semi-automatic seeded image segmentation method, based on a cellular automata model, for MRI brain cancer detection and delineation is proposed. This approach, called GTVcut, employs an adaptive seed selection strategy and helps to segment the GTV, by identifying the target volume to be treated using the Gamma Knife device. The accuracy of GTVcut was evaluated on a dataset composed of 32 brain cancers, using both spatial overlap-based and distance-based metrics. The achieved experimental results are very reproducible, showing the effectiveness and the clinical feasibility of the proposed approach.
Articolo in rivista - Articolo scientifico
Brain cancers; Cellular automata; Computer-assisted segmentation; Gamma Knife neuro-radiosurgery; MR imaging;
Brain cancers; Cellular automata; Computer-assisted segmentation; Gamma Knife neuro-radiosurgery; MR imaging; Computer Science Applications1707 Computer Vision and Pattern Recognition
English
31-lug-2017
2018
17
3
521
536
none
Rundo, L., Militello, C., Russo, G., Vitabile, S., Gilardi, M., Mauri, G. (2018). GTVcut for neuro-radiosurgery treatment planning: an MRI brain cancer seeded image segmentation method based on a cellular automata model. NATURAL COMPUTING, 17(3), 521-536 [10.1007/s11047-017-9636-z].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/168703
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