The synthesis of novel hyperbranched monodisperse linear dendrimers, based on 2,2-bis-(hydroxymethyl)-propionic acid (bis-MPA), has been achieved by convergent metathesis-mediated coupling between the alkene-terminated focal point of bis-MPA dendrons. On their surface, dendrimers present 4, 8 and 16 functional groups. Glycodendrimers exposing multiple saccharide moieties have also been obtained. To the best of our knowledge, this is the first example of the use of metathesis for focal point coupling.
Guizzardi, R., Vacchini, M., Santambrogio, C., Cipolla, L. (2017). Convergent dendrimer synthesis by olefin metathesis and studies toward glycoconjugation. CANADIAN JOURNAL OF CHEMISTRY, 95(9), 1008-1012 [10.1139/cjc-2017-0146].
Convergent dendrimer synthesis by olefin metathesis and studies toward glycoconjugation
GUIZZARDI, ROBERTOPrimo
;VACCHINI, MATTIASecondo
;SANTAMBROGIO, CARLOPenultimo
;CIPOLLA, LAURA FRANCESCA
Ultimo
2017
Abstract
The synthesis of novel hyperbranched monodisperse linear dendrimers, based on 2,2-bis-(hydroxymethyl)-propionic acid (bis-MPA), has been achieved by convergent metathesis-mediated coupling between the alkene-terminated focal point of bis-MPA dendrons. On their surface, dendrimers present 4, 8 and 16 functional groups. Glycodendrimers exposing multiple saccharide moieties have also been obtained. To the best of our knowledge, this is the first example of the use of metathesis for focal point coupling.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
