IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishOBJECTIVE - This study was performed to ascertain whether insulin resistance with respect to protein metabolism is an additional primary metabolic abnormality affecting insulin-resistant offspring of type 2 diabetic parents, along with insulin resistance with respect to glucose and lipid metabolism. DESIGN AND METHODS - We studied 18 young, nonobese offspring of type 2 diabetic parents and 27 healthy matched (by means of dual-energy X-ray absorption) individuals with the bolus plus continuous infusion of [6,6-2H 2]glucose and [l-13C]leucine in combination with the insulin clamp (40 mU · m-2 · min-1). RESULTS - Fasting plasma leucine, phenylalanine, alanine, and glutamine concentrations, as well as the glucose and leucine turnover (reciprocal pool model: 155 ± 10 vs. 165 ± 5 μmol · kg lean body mass-1 · h-1 in offspring of type 2 diabetic patients and healthy matched individuals, respectively), were also not different. During the clamp, glucose turnover rates were significantly reduced in offspring of type 2 diabetic patients (7.1 ± 0.5) in comparison with healthy matched individuals (9.9 ± 0.6 mg · kg lean body mass-1 · min-1; P < 0.01). Also, the suppression of leucine turnover was impaired in offspring of type 2 diabetic patients (12 ± 1%) in comparison with healthy matched individuals (17 ± 1%; P = 0.04) and correlated with the degree of the impairment of insulin-stimulated glucose metabolism (R2 = 0.13; P = 0.02). CONCLUSIONS - Nonobese, nondiabetic, insulin-resistant offspring of type 2 diabetic patients were characterized by an impairment of insulin-dependent suppression of protein breakdown, which was proportional to the impairment of glucose metabolism. These results demonstrate that in humans, a primary in vivo impairment of insulin action affects glucose and fatty acid metabolism as previously shown and also protein/amino acid metabolism
Lattuada, G., Sereni, L., Ruggieri, D., Scollo, A., Benedini, S., Ragogna, F., et al. (2004). Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of type 2 diabetic patients. DIABETES CARE, 27(11), 2716-2722 [10.2337/diacare.27.11.2716].
| Citazione: | Lattuada, G., Sereni, L., Ruggieri, D., Scollo, A., Benedini, S., Ragogna, F., et al. (2004). Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of type 2 diabetic patients. DIABETES CARE, 27(11), 2716-2722 [10.2337/diacare.27.11.2716]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of type 2 diabetic patients | |
| Autori: | Lattuada, G; Sereni, L; Ruggieri, D; Scollo, A; Benedini, S; Ragogna, F; Costantino, F; Battezzati, A; Luzi, L; Perseghin, G | |
| Autori: | PERSEGHIN, GIANLUCA (Ultimo) | |
| Data di pubblicazione: | 2004 | |
| Lingua: | English | |
| Rivista: | DIABETES CARE | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2337/diacare.27.11.2716 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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