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EnglishObjective: Exercise training may cause changes in thyroid function. This thyroid response may be due to exercise-induced modulation of energy metabolism but also of the adipocytes endocrine function. In particular, the role of leptin and of circulating soluble leptin receptor (sOB-R) was unexplored. The aim of this study was to assess the relationships between thyroid function, whole body energy metabolism, and adipokines - mainly leptin and its receptor, sOB-R. Methods: We measured serum TSH, free tri-iodothyronine (FT3), free thyroxine, leptin, and sOB-R and assessed energy homeostasis by means of indirect calorimetry, in 27 highly trained athletes and 27 sedentary, healthy men. Results: TSH-FT3 ratio was lower in athletes (P < 0.03), either in sustained power or anaerobic powersprint athletes (n = 13) or marathon runners (n = 14). Whole body respiratory quotient was lower in athletes. Fasting serum sOB-R was higher and leptin lower in athletes than controls. Also serum adiponectin, resistin, and retinol binding protein-4 concentrations were different in athletes than in controls. The ratio between leptin and sOB-R, the free leptin index (FLI), was lower in athletes than in controls (0.025 ± 0.014 vs 0.085 ± 0.049; P < 0.001). In multivariate analysis, FLI retained independent association with TSH-FT3 ratio. Conclusion: Male, elite athletes had lower TSH-FT3 ratio and FLI than controls while FLI was independently associated with TSH-FT3 ratio supporting the hypothesis that the level of biologically active leptin is involved in the adaptive response of thyroid function in professional athletes. © 2009 European Society of Endocrinology
Perseghin, G., Lattuada, G., Ragogna, F., Alberti, G., La Torre, A., & Luzi, L. (2009). Free leptin index and thyroid function in male highly trained athletes. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(6), 871-876 [10.1530/EJE-09-0569].
| Citazione: | Perseghin, G., Lattuada, G., Ragogna, F., Alberti, G., La Torre, A., & Luzi, L. (2009). Free leptin index and thyroid function in male highly trained athletes. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(6), 871-876 [10.1530/EJE-09-0569]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Free leptin index and thyroid function in male highly trained athletes | |
| Autori: | Perseghin, G; Lattuada, G; Ragogna, F; Alberti, G; La Torre, A; Luzi, L | |
| Autori: | PERSEGHIN, GIANLUCA (Primo) | |
| Data di pubblicazione: | 2009 | |
| Lingua: | English | |
| Rivista: | EUROPEAN JOURNAL OF ENDOCRINOLOGY | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1530/EJE-09-0569 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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