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IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
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English31P-magnetic resonance spectroscopy (31P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enrolled. Nine of them received short-term low-dose Valsartan treatment (80 mg/day) for 6 months, while 11 controls received no medication. Kidney HEP metabolism was evaluated both at baseline and after treatment by 31P-MRS with a 1.5 T system (Gyroscan Intera Master 1.5 MR System; Philips Medical Systems, Best, The Netherlands). Valsartan-treated patients (n = 9) showed a significant increase in β-ATP/Pi ratio, a marker of kidney HEP metabolism (baseline = 1.03 ± 0.08 vs. 6 months = 1.26 ± 0.07, p = 0.03). In contrast, the β-ATP/Pi ratio in the control group (n = 11) did not change (baseline = 0.85 ± 0.10 vs. 6 months = 0.89 ± 0.08, ns). The improvement in the β-ATP/Pi ratio was not associated with a reduction in arterial blood pressure or in urinary albumin excretion. Kidney-localized 31P-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients. © 2012 Springer-Verlag
Fiorina, P., Bassi, R., Gremizzi, C., Vergani, A., Caldara, R., Mello, A., et al. (2012). 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients. ACTA DIABETOLOGICA, 49(1 SUPPL), S133-S139 [10.1007/s00592-012-0369-2].
| Citazione: | Fiorina, P., Bassi, R., Gremizzi, C., Vergani, A., Caldara, R., Mello, A., et al. (2012). 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients. ACTA DIABETOLOGICA, 49(1 SUPPL), S133-S139 [10.1007/s00592-012-0369-2]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients | |
| Autori: | Fiorina, P; Bassi, R; Gremizzi, C; Vergani, A; Caldara, R; Mello, A; Del Maschio, A; De Cobelli, F; Perseghin, G; Secchi, A | |
| Autori: | PERSEGHIN, GIANLUCA (Penultimo) | |
| Data di pubblicazione: | 2012 | |
| Lingua: | English | |
| Rivista: | ACTA DIABETOLOGICA | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00592-012-0369-2 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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