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English31P-magnetic resonance spectroscopy (31P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enrolled. Nine of them received short-term low-dose Valsartan treatment (80 mg/day) for 6 months, while 11 controls received no medication. Kidney HEP metabolism was evaluated both at baseline and after treatment by 31P-MRS with a 1.5 T system (Gyroscan Intera Master 1.5 MR System; Philips Medical Systems, Best, The Netherlands). Valsartan-treated patients (n = 9) showed a significant increase in β-ATP/Pi ratio, a marker of kidney HEP metabolism (baseline = 1.03 ± 0.08 vs. 6 months = 1.26 ± 0.07, p = 0.03). In contrast, the β-ATP/Pi ratio in the control group (n = 11) did not change (baseline = 0.85 ± 0.10 vs. 6 months = 0.89 ± 0.08, ns). The improvement in the β-ATP/Pi ratio was not associated with a reduction in arterial blood pressure or in urinary albumin excretion. Kidney-localized 31P-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients. © 2012 Springer-Verlag
Fiorina, P., Bassi, R., Gremizzi, C., Vergani, A., Caldara, R., Mello, A., et al. (2012). 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients. ACTA DIABETOLOGICA, 49(1 SUPPL), S133-S139 [10.1007/s00592-012-0369-2].
| Citazione: | Fiorina, P., Bassi, R., Gremizzi, C., Vergani, A., Caldara, R., Mello, A., et al. (2012). 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients. ACTA DIABETOLOGICA, 49(1 SUPPL), S133-S139 [10.1007/s00592-012-0369-2]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients | |
| Autori: | Fiorina, P; Bassi, R; Gremizzi, C; Vergani, A; Caldara, R; Mello, A; Del Maschio, A; De Cobelli, F; Perseghin, G; Secchi, A | |
| Autori: | PERSEGHIN, GIANLUCA (Penultimo) | |
| Data di pubblicazione: | 2012 | |
| Lingua: | English | |
| Rivista: | ACTA DIABETOLOGICA | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00592-012-0369-2 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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