Aim: Data on left ventricular hypertrophy (LVH) in patients with renal artery stenosis (RAS) and its regression following renal revascularization are scanty. We performed a meta-analysis to provide comprehensive information on this clinically relevant issue. Methods: Full articles providing data on: LVH, as assessed by echocardiography, in RAS patients as compared with essential hypertensive counterparts; changes of left ventricular (LV) mass index after renal artery revascularization were considered. Results: A total of 905 study participants (RAS=446, essential hypertensive=459) of both sex were included in nine studies. Pooled LV mass index was higher in RAS than in essential hypertensive patients (140.4±11.1g/m 2 versus 121.8±6.2g/m 2, standard mean difference being 0.41±0.07 [95% confidence interval (CI) 0.27-0.51, P<0.001]. Among 360 RAS patients undergone renal revascularization from eight studies, baseline and post-intervention pooled mean LV mass index values were 129.0±10.2g/m 2 and 115.5±9.9g/m 2, respectively, the standard mean difference being-0.36±0.06 (95% CI from -0.47 to -0.25, P<0.001). These findings were unaffected by publication bias or single study effect. Conclusion: Our meta-analysis indicates that RAS patients have an increased likelihood of LVH compared with essential hypertensive counterparts and renal artery revascularization has a beneficial effect on LV structure, as reflected by a significant decrease in LV mass index.
Cuspidi, C., Dell'Oro, R., Sala, C., Tadic, M., Gherbesi, E., Grassi, G., et al. (2017). Renal artery stenosis and left ventricular hypertrophy: an updated review and meta-analysis of echocardiographic studies. JOURNAL OF HYPERTENSION, 35(12), 2339-2345.
|Citazione:||Cuspidi, C., Dell'Oro, R., Sala, C., Tadic, M., Gherbesi, E., Grassi, G., et al. (2017). Renal artery stenosis and left ventricular hypertrophy: an updated review and meta-analysis of echocardiographic studies. JOURNAL OF HYPERTENSION, 35(12), 2339-2345.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Renal artery stenosis and left ventricular hypertrophy: an updated review and meta-analysis of echocardiographic studies.|
|Autori:||Cuspidi, C; Dell'Oro, R; Sala, C; Tadic, M; Gherbesi, E; Grassi, G; Mancia, G|
CUSPIDI, CESARE (Corresponding)
|Data di pubblicazione:||2017|
|Rivista:||JOURNAL OF HYPERTENSION|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/HJH.0000000000001500|
|Appare nelle tipologie:||01 - Articolo su rivista|