The most studied physiological function of biliary epithelial cells (cholangiocytes) is to regulate bile flow and composition, in particular the hydration and alkalinity of the primary bile secreted by hepatocytes. After almost three decades of studies it is now become clear that cholangiocytes are also involved in epithelial innate immunity, in inflammation, and in the reparative processes in response to liver damage. An increasing number of evidence highlights the ability of cholangiocyte to undergo changes in phenotype and function in response to liver damage. By participating actively to the immune and inflammatory responses, cholangiocytes represent a first defense line against liver injury from different causes. Indeed, cholangiocytes express a number of receptors able to recognize pathogen- or damage-associated molecular patterns (PAMPs/DAMPs), such as Toll-like receptors (TLR), which modulate their pro-inflammatory behavior. Cholangiocytes can be both the targets and the initiators of the inflammatory process. Derangements of the signals controlling these mechanisms are at the basis of the pathogenesis of different cholangiopathies, both hereditary and acquired, such as cystic fibrosis-related liver disease and sclerosing cholangitis. This article is part of a Special Issue entitled: Cholangiocytes in Health and Diseaseedited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen

Strazzabosco, M., Fiorotto, R., Cadamuro, M., Spirli, C., Mariotti, V., Kaffe, E., et al. (2018). Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, 1864(4), 1374-1379 [10.1016/j.bbadis.2017.07.023].

Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium

STRAZZABOSCO, MARIO
Primo
;
CADAMURO, MASSIMILIANO;SCIRPO, ROBERTO
Penultimo
;
2018

Abstract

The most studied physiological function of biliary epithelial cells (cholangiocytes) is to regulate bile flow and composition, in particular the hydration and alkalinity of the primary bile secreted by hepatocytes. After almost three decades of studies it is now become clear that cholangiocytes are also involved in epithelial innate immunity, in inflammation, and in the reparative processes in response to liver damage. An increasing number of evidence highlights the ability of cholangiocyte to undergo changes in phenotype and function in response to liver damage. By participating actively to the immune and inflammatory responses, cholangiocytes represent a first defense line against liver injury from different causes. Indeed, cholangiocytes express a number of receptors able to recognize pathogen- or damage-associated molecular patterns (PAMPs/DAMPs), such as Toll-like receptors (TLR), which modulate their pro-inflammatory behavior. Cholangiocytes can be both the targets and the initiators of the inflammatory process. Derangements of the signals controlling these mechanisms are at the basis of the pathogenesis of different cholangiopathies, both hereditary and acquired, such as cystic fibrosis-related liver disease and sclerosing cholangitis. This article is part of a Special Issue entitled: Cholangiocytes in Health and Diseaseedited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen
Articolo in rivista - Review Essay
Cholangiocytes; Cytokines; Inflammasome; Inflammation; Toll-like receptor; Molecular Medicine; Molecular Biology
English
2018
1864
4
1374
1379
none
Strazzabosco, M., Fiorotto, R., Cadamuro, M., Spirli, C., Mariotti, V., Kaffe, E., et al. (2018). Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, 1864(4), 1374-1379 [10.1016/j.bbadis.2017.07.023].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/164471
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