Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

Deban, L., Russo, R., Sironi, M., Moalli, F., Scanziani, M., Zambelli, V., et al. (2010). Regulation of leukocyte recruitment by the long pentraxin PTX3. NATURE IMMUNOLOGY, 11(4), 328-334 [10.1038/ni.1854].

Regulation of leukocyte recruitment by the long pentraxin PTX3

SCANZIANI, MARGHERITA;ZAMBELLI, VANESSA;
2010

Abstract

Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.
Articolo in rivista - Articolo scientifico
CHO Cells; Acute Lung Injury; Cricetinae; Electrophoresis, Polyacrylamide Gel; Mice, Knockout; Animals; Cell Separation; Humans; Serum Amyloid P-Component; Flow Cytometry; Inflammation; Recombinant Proteins; Mice; Mice, Inbred C57BL; Leukocyte Rolling; Neutrophil Infiltration; C-Reactive Protein; Cricetulus; Immunity, Humoral;
English
2010
11
4
328
334
none
Deban, L., Russo, R., Sironi, M., Moalli, F., Scanziani, M., Zambelli, V., et al. (2010). Regulation of leukocyte recruitment by the long pentraxin PTX3. NATURE IMMUNOLOGY, 11(4), 328-334 [10.1038/ni.1854].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/16009
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