This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2−/− mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2−/− causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2−/− mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum.

Valle, G., Vergani, B., Sacchetto, R., Reggiani, C., De Rosa, E., Maccatrozzo, L., et al. (2016). Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 37(6), 225-233 [10.1007/s10974-016-9463-3].

Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only

VERGANI, BARBARA
Secondo
;
VILLA, ANTONELLO
Penultimo
;
2016

Abstract

This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2−/− mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2−/− causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2−/− mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum.
Articolo in rivista - Articolo scientifico
Adaptation; Calsequestrin; Knock-out mice; Skeletal muscle;
Adaptation; Calsequestrin; Knock-out mice; Skeletal muscle; Physiology; Biochemistry; Cell Biology
English
225
233
9
Valle, G., Vergani, B., Sacchetto, R., Reggiani, C., De Rosa, E., Maccatrozzo, L., et al. (2016). Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 37(6), 225-233 [10.1007/s10974-016-9463-3].
Valle, G; Vergani, B; Sacchetto, R; Reggiani, C; De Rosa, E; Maccatrozzo, L; Nori, A; Villa, A; Volpe, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/159496
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