IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishUsing immunocytochemical assays and patch-clamp and calcium-imaging recordings, we demonstrate that L-type and N-type calcium channels have distinct patterns of expression and distribution and play different functional roles during hippocampal neuron differentiation. L-type channels, which support the depolarization-induced calcium influx in neurons from the very early developmental stages, are functionally restricted to the somatodendritic compartment throughout neuronal development and play a crucial role in supporting neurite outgrowth at early developmental stages. N-type channels, which start contributing at later neuronal differentiation stages (3-4 DIV), are also functionally expressed in the axons of immature neurons. At this developmental stage preceding synaptogenesis, N-type (but not L-type) channels are involved in controlling synaptic vesicle recycling. It is only at later developmental stages (10-12 DIV), when the neurons have established a clear axodendritic polarity and form synaptic contacts, that N-type channels are progressively excluded from the axon. Electrophysiological recordings of single neurons growing in microislands revealed that synaptic maturation coincides with a progressive increase in N-type channels in the somatodendritic region and a progressive decrease in the N-type channels supporting glutamate release from the presynaptic terminal. These results indicate that L-type and N-type calcium channels undergo dynamic, developmentally regulated rearrangements in regional distribution and function and also suggest that different mechanisms may be involved in the sorting and/or stabilization of these two types of channels in different plasma membrane domains during neuronal differentiation. (C) 2000 Academic Press.
Pravettoni, E., Bacci, A., Coco, S., Forbicini, P., Matteoli, M., & Verderio, C. (2000). Different localizations and functions of L-type and N-type calcium channels during development of hippocampal neurons. DEVELOPMENTAL BIOLOGY, 227(2), 581-594.
| Citazione: | Pravettoni, E., Bacci, A., Coco, S., Forbicini, P., Matteoli, M., & Verderio, C. (2000). Different localizations and functions of L-type and N-type calcium channels during development of hippocampal neurons. DEVELOPMENTAL BIOLOGY, 227(2), 581-594. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Different localizations and functions of L-type and N-type calcium channels during development of hippocampal neurons | |
| Autori: | Pravettoni, E; Bacci, A; Coco, S; Forbicini, P; Matteoli, M; Verderio, C | |
| Autori: | ||
| Data di pubblicazione: | 2000 | |
| Lingua: | English | |
| Rivista: | DEVELOPMENTAL BIOLOGY | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1006/dbio.2000.9872 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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