The purpose of this study was to identify the most cost-effective method for screening subjects for hepatitis B vaccination. Such a method would ideally permit detection of all susceptible individuals at the lowest possible cost. Two-hundred-five hospital workers from the Piedmont region of Italy participated in the study. The sero-epidemiological conditions of this group with regard to hepatitis B markers was representative of hospital workers in this region as a whole. All subjects, excluding carriers, persons with anti-HBs titers greater than or equal to 10 mIU and subjects positive for anti-HBc at a 1/100 dilution, were vaccinated. Their responses were evaluated 15 days and 1 month after vaccination. The presence of a booster effect following vaccination was correlated with the immunological status of the subject at the time of pre-vaccination screening. In the light of the results obtained, 5 screening procedures and the procedure of vaccination without screening were evaluated. The most cost effective screening strategy proved to be that of sequential testing for anti-HBc, anti-HBs and finally HBsAg and vaccination of the following subjects: those who were negative for anti-HBc, those who were anti-HBc-positive with anti-HBs titers 10 less than mIU and those who were HBsAg negative.
Corrao, G., Zotti, C., Tinivella, F., & Moiraghi Ruggenini, A. (1987). HBV pre-vaccination screening in hospital personnel: cost-effectiveness analysis. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 3(1), 25-29.
|Citazione:||Corrao, G., Zotti, C., Tinivella, F., & Moiraghi Ruggenini, A. (1987). HBV pre-vaccination screening in hospital personnel: cost-effectiveness analysis. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 3(1), 25-29.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||HBV pre-vaccination screening in hospital personnel: cost-effectiveness analysis|
|Autori:||Corrao, G; Zotti, C; Tinivella, F; Moiraghi Ruggenini, A|
|Data di pubblicazione:||mar-1987|
|Rivista:||EUROPEAN JOURNAL OF EPIDEMIOLOGY|
|Appare nelle tipologie:||01 - Articolo su rivista|