Our aims were to design a reproducible method of measuring life-time alcohol consumption in patients with cirrhosis, and to assess the risk of liver decompensation associated with alcohol intake using a case-control design and a multivariate analysis. We studied 439 patients ("cases") with decompensated cirrhosis, and 233 with compensated cirrhosis ("controls"). Mean life-time daily amount and duration of alcohol intake were measured by a standardized questionnaire, whose reproducibility, assessed by interviewing 75 relatives, was 70% for daily alcohol intake and 84% for duration of intake. Better reproducibility was found by re-interviewing patients at discharge from hospital. Daily alcohol intake was significantly higher in males, younger patients and patients with liver decompensation. After stratification according to the average life-time daily alcohol intake, we found a significant increase in the risk of liver decompensation from 125 g ethanol intake per day onwards. No association was found between duration of alcohol intake and risk of liver decompensation. We conclude that alcohol intake can be reliably and reproducibly measured: in patients with cirrhosis, increased alcohol intake is associated with increased risk of liver decompensation, with a significant dose-effect above a daily intake of 125 g ethanol

Arico, S., Galatola, G., Tabone, M., Corrao, G., Torchio, P., Valenti, M., et al. (1995). The measure of life‐time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance. LIVER, 15(4), 202-208 [10.1111/j.1600-0676.1995.tb00671.x].

The measure of life‐time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance

CORRAO, GIOVANNI;
1995

Abstract

Our aims were to design a reproducible method of measuring life-time alcohol consumption in patients with cirrhosis, and to assess the risk of liver decompensation associated with alcohol intake using a case-control design and a multivariate analysis. We studied 439 patients ("cases") with decompensated cirrhosis, and 233 with compensated cirrhosis ("controls"). Mean life-time daily amount and duration of alcohol intake were measured by a standardized questionnaire, whose reproducibility, assessed by interviewing 75 relatives, was 70% for daily alcohol intake and 84% for duration of intake. Better reproducibility was found by re-interviewing patients at discharge from hospital. Daily alcohol intake was significantly higher in males, younger patients and patients with liver decompensation. After stratification according to the average life-time daily alcohol intake, we found a significant increase in the risk of liver decompensation from 125 g ethanol intake per day onwards. No association was found between duration of alcohol intake and risk of liver decompensation. We conclude that alcohol intake can be reliably and reproducibly measured: in patients with cirrhosis, increased alcohol intake is associated with increased risk of liver decompensation, with a significant dose-effect above a daily intake of 125 g ethanol
Articolo in rivista - Articolo scientifico
Male; Time Factors; Liver Cirrhosis, Alcoholic; Middle Aged; Female; Risk Factors; Italy; Questionnaires; Alcohol Drinking; Humans; Age Factors; Hepatitis B; Regression Analysis; Sex Factors; Reproducibility of Results; Adult; Case-Control Studies
English
1995
15
4
202
208
none
Arico, S., Galatola, G., Tabone, M., Corrao, G., Torchio, P., Valenti, M., et al. (1995). The measure of life‐time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance. LIVER, 15(4), 202-208 [10.1111/j.1600-0676.1995.tb00671.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/15864
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