Preeclampsia is a multisystem disorder affecting 2% to 8% of pregnancies and a leading cause of maternal and perinatal morbidity and mortality worldwide. Recent investigations have improved our understanding of the pathogenesis of this potentially life-threatening disease, especially in its early-onset form of manifestation. Despite these advances, therapeutic options are still limited and no effective pharmacologic interventions are currently available. Ongoing lines of research indicate some potential novel treatments targeting specific pathogenic steps. In this article we provide an updated overview of the multiple therapeutic approaches under preclinical and clinical assessment for the treatment of early-onset preeclampsia.

Ornaghi, S., Paidas, M. (2017). Novel Therapy for the Treatment of Early-Onset Preeclampsia. CLINICAL OBSTETRICS AND GYNECOLOGY, 60(1), 169-182 [10.1097/GRF.0000000000000249].

Novel Therapy for the Treatment of Early-Onset Preeclampsia

ORNAGHI, SARA
Primo
;
2017

Abstract

Preeclampsia is a multisystem disorder affecting 2% to 8% of pregnancies and a leading cause of maternal and perinatal morbidity and mortality worldwide. Recent investigations have improved our understanding of the pathogenesis of this potentially life-threatening disease, especially in its early-onset form of manifestation. Despite these advances, therapeutic options are still limited and no effective pharmacologic interventions are currently available. Ongoing lines of research indicate some potential novel treatments targeting specific pathogenic steps. In this article we provide an updated overview of the multiple therapeutic approaches under preclinical and clinical assessment for the treatment of early-onset preeclampsia.
Articolo in rivista - Review Essay
angiogenic imbalance; endothelial dysfunction.; inflammation; placenta; preeclampsia;
English
169
182
14
Ornaghi, S., Paidas, M. (2017). Novel Therapy for the Treatment of Early-Onset Preeclampsia. CLINICAL OBSTETRICS AND GYNECOLOGY, 60(1), 169-182 [10.1097/GRF.0000000000000249].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/157358
Citazioni
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 11
Social impact