The immune system has evolved to protect multicellular organisms from the attack of a variety of pathogens. To exert this function efficiently, thesystemhas developed the capacity to coordinate the function of different cell types and the ability to down-modulate the response when the foreign attack is over. For decades, immunologists believed that these two characteristics were primarily related to cytokine/chemokine-based communication and cell-to-cell direct contact. More recently, it has been shown that immune cells also communicate by transferring regulatory RNAs, microRNAsin particular, from one cell to the other. Several studies have suggested a functional role of extracellular regulatory RNAs in cell-to-cellcommunicationin different cellular contexts. This minireview focuses on the potential role of extracellularRNAtransfer in the regulation of adaptive immune response, also contextualizing it in a broader field of what is known of cell-free RNAs in communication among different organisms in the evolutionary scale.
De Candia, P., De Rosa, V., Casiraghi, M., & Matarese, G. (2016). Extracellular RNAs: A secret arm of immune system regulation. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 291(14), 7221-7228 [10.1074/jbc.R115.708842].
|Citazione:||De Candia, P., De Rosa, V., Casiraghi, M., & Matarese, G. (2016). Extracellular RNAs: A secret arm of immune system regulation. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 291(14), 7221-7228 [10.1074/jbc.R115.708842].|
|Tipo:||Articolo in rivista - Review Essay|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Extracellular RNAs: A secret arm of immune system regulation|
|Autori:||De Candia, P; De Rosa, V; Casiraghi, M; Matarese, G|
CASIRAGHI, MAURIZIO (Penultimo)
|Data di pubblicazione:||2016|
|Rivista:||THE JOURNAL OF BIOLOGICAL CHEMISTRY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1074/jbc.R115.708842|
|Appare nelle tipologie:||01 - Articolo su rivista|