Previous studies on squamous cell carcinoma of the tongue have reported conflicting results with respect to age and prognosis. The aim of this study is to elucidate if any differences in outcome exist between patients younger and older than 40 years. A case-control study was performed. Patients recorded in the head and neck cancer registry of Milano-Bicocca School of Medicine between January 1981 and December 1998 were reviewed. Cases were patients with squamous cell carcinoma of the tongue aged 40 years or less. Controls were patients older than 40 who were matched to cases for diagnosis, sex and TNM classification. Two controls were matched for each case, thus forty-six cases and 92 controls were selected. The frequency of recurrences was found to be significantly higher in younger patients. The survival analysis further supports this conclusion (log-rank test, p=0.002). The number of cancer-related deaths in patients younger and older than 40 years were 23 (50%) and 31 (34%), respectively (p=0.10). A statistical significant difference emerged when the number of deaths was compared using survival curves (log-rank test, p=0.05). In conclusion, in patients with squamous cell carcinoma of the tongue, young age is an independent predictor of worse survival.

Garavello, W., Spreafico, R., Gaini, R. (2007). Oral tongue cancer in young patients: a matched analysis. ORAL ONCOLOGY, 43(9), 894-897 [10.1016/j.oraloncology.2006.10.013].

Oral tongue cancer in young patients: a matched analysis

GARAVELLO, WERNER;GAINI, RENATO MARIA
2007

Abstract

Previous studies on squamous cell carcinoma of the tongue have reported conflicting results with respect to age and prognosis. The aim of this study is to elucidate if any differences in outcome exist between patients younger and older than 40 years. A case-control study was performed. Patients recorded in the head and neck cancer registry of Milano-Bicocca School of Medicine between January 1981 and December 1998 were reviewed. Cases were patients with squamous cell carcinoma of the tongue aged 40 years or less. Controls were patients older than 40 who were matched to cases for diagnosis, sex and TNM classification. Two controls were matched for each case, thus forty-six cases and 92 controls were selected. The frequency of recurrences was found to be significantly higher in younger patients. The survival analysis further supports this conclusion (log-rank test, p=0.002). The number of cancer-related deaths in patients younger and older than 40 years were 23 (50%) and 31 (34%), respectively (p=0.10). A statistical significant difference emerged when the number of deaths was compared using survival curves (log-rank test, p=0.05). In conclusion, in patients with squamous cell carcinoma of the tongue, young age is an independent predictor of worse survival.
Articolo in rivista - Articolo scientifico
Aged, 80 and over; Linear Models; Male; Survival Rate; Middle Aged; Survival Analysis; Female; Neoplasm Recurrence, Local; Tongue Neoplasms; Neoplasm Staging; Disease-Free Survival; Registries; Humans; Age Factors; Aged; Adult; Carcinoma, Squamous Cell; Case-Control Studies
English
ott-2007
43
9
894
897
none
Garavello, W., Spreafico, R., Gaini, R. (2007). Oral tongue cancer in young patients: a matched analysis. ORAL ONCOLOGY, 43(9), 894-897 [10.1016/j.oraloncology.2006.10.013].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/15312
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