Aim: We investigate MAdCAM-1 as a reliable target to detect active bowel inflammation for selective noninvasive nanodiagnostics. Materials & methods: We coupled anti-MAdCAM-1 antibodies to manganese oxide nanoparticles, and analyzed nanoconjugate biodistribution and safety in murine model of inflammatory bowel disease by imaging and histology. Results: Nanoparticles were stable and nontoxic. Upon administration in colitic mice, anti-MAdCAM-1 functionalized nanoparticles preferentially localized in the inflamed bowel, whereas untargeted nanoparticles were more rapidly washed out. Nanoparticles did not induce lesions in nontarget organs. Conclusion: Anti-MAdCAM-1 functionalized nanoparticles detected active bowel inflammation foci, accurately following MAdCAM-1 expression pattern. These nanoconjugates could be a promising noninvasive imaging system for an early and accurate follow-up in patients affected by acute colitis.

Truffi, M., Colombo, M., Peñaranda Avila, J., Sorrentino, L., Monieri, M., Collico, V., et al. (2017). Nano-targeting of Mucosal Addressin Cell Adhesion Molecule-1 identifies bowel inflammation foci in murine model. NANOMEDICINE, 12(13), 1547-1560 [10.2217/nnm-2017-0004].

Nano-targeting of Mucosal Addressin Cell Adhesion Molecule-1 identifies bowel inflammation foci in murine model

COLOMBO, MIRIAM
Secondo
;
COLLICO, VERONICA;PROSPERI, DAVIDE
Penultimo
;
2017

Abstract

Aim: We investigate MAdCAM-1 as a reliable target to detect active bowel inflammation for selective noninvasive nanodiagnostics. Materials & methods: We coupled anti-MAdCAM-1 antibodies to manganese oxide nanoparticles, and analyzed nanoconjugate biodistribution and safety in murine model of inflammatory bowel disease by imaging and histology. Results: Nanoparticles were stable and nontoxic. Upon administration in colitic mice, anti-MAdCAM-1 functionalized nanoparticles preferentially localized in the inflamed bowel, whereas untargeted nanoparticles were more rapidly washed out. Nanoparticles did not induce lesions in nontarget organs. Conclusion: Anti-MAdCAM-1 functionalized nanoparticles detected active bowel inflammation foci, accurately following MAdCAM-1 expression pattern. These nanoconjugates could be a promising noninvasive imaging system for an early and accurate follow-up in patients affected by acute colitis.
Articolo in rivista - Articolo scientifico
manganese oxide nanoparticle, MAdCAM-1, inflammatory bowel disease
English
2017
12
13
1547
1560
none
Truffi, M., Colombo, M., Peñaranda Avila, J., Sorrentino, L., Monieri, M., Collico, V., et al. (2017). Nano-targeting of Mucosal Addressin Cell Adhesion Molecule-1 identifies bowel inflammation foci in murine model. NANOMEDICINE, 12(13), 1547-1560 [10.2217/nnm-2017-0004].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/152677
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