The EuroSciCon's 2015 Innate Immunity Summit, London, UK, 17-19 November 2015 A first line of defense against viral infection is prompted by the innate immune system. Viruses activate both extracellular and intracellular events that lead to a war between the virus and the host. In addition to vaccines which induce adaptive T- and B-cell response in readiness for infection, other therapies that potentiate the host immune response are in development, such as those that induce an increase in restriction factor activity or diminish inflammation through Toll-like receptors' antagonists. Other modulators of immune response, such as thymosin α-1, contribute to the inhibition of HIV-1 and human T lymphotropic virus 1 infection. Understanding the mechanisms by which the innate immune response combats pathogen invasion will enable the generation of novel therapeutic strategies to cure viral infection.

Camprubí Rimblas, M., Peri, F., Mcknight, Á., Matteucci, C., Guillamat Prats, R. (2016). The EuroSciCon's 2015 Innate Immunity Summit. FUTURE VIROLOGY, 11(10), 665-669 [10.2217/fvl-2016-0091].

The EuroSciCon's 2015 Innate Immunity Summit

PERI, FRANCESCO
Secondo
;
2016

Abstract

The EuroSciCon's 2015 Innate Immunity Summit, London, UK, 17-19 November 2015 A first line of defense against viral infection is prompted by the innate immune system. Viruses activate both extracellular and intracellular events that lead to a war between the virus and the host. In addition to vaccines which induce adaptive T- and B-cell response in readiness for infection, other therapies that potentiate the host immune response are in development, such as those that induce an increase in restriction factor activity or diminish inflammation through Toll-like receptors' antagonists. Other modulators of immune response, such as thymosin α-1, contribute to the inhibition of HIV-1 and human T lymphotropic virus 1 infection. Understanding the mechanisms by which the innate immune response combats pathogen invasion will enable the generation of novel therapeutic strategies to cure viral infection.
Articolo in rivista - Review Essay
complement system; innate immunity; macrophages (M1/M2); restriction factors; T cells (Th1/Th2); thymosin α-1; Toll-like receptors;
complement system; innate immunity; macrophages (M1/M2); restriction factors; T cells (Th1/Th2); thymosin α-1; Toll-like receptors; Virology
English
665
669
5
Camprubí Rimblas, M., Peri, F., Mcknight, Á., Matteucci, C., Guillamat Prats, R. (2016). The EuroSciCon's 2015 Innate Immunity Summit. FUTURE VIROLOGY, 11(10), 665-669 [10.2217/fvl-2016-0091].
File in questo prodotto:
File Dimensione Formato  
fvl-2016-0091.pdf

Solo gestori archivio

Dimensione 1.08 MB
Formato Adobe PDF
1.08 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/152490
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
Social impact