Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS

Ferrarese, C., Sala, G., Riva, R., Begni, B., Zoia, C., Tremolizzo, L., et al. (2001). Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis. NEUROLOGY, 56(2), 270-272 [10.1212/WNL.56.2.270].

Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis

Ferrarese, C;Sala, G;Zoia, CP;Tremolizzo, L;Galimberti, G;
2001

Abstract

Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS
Articolo in rivista - Articolo scientifico
Glutamic Acid; Analysis of Variance; Amyotrophic Lateral Sclerosis; Male; Middle Aged; Blood Platelets; Biological Markers; Female; Aged; Adult; Humans
English
270
272
3
Ferrarese, C., Sala, G., Riva, R., Begni, B., Zoia, C., Tremolizzo, L., et al. (2001). Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis. NEUROLOGY, 56(2), 270-272 [10.1212/WNL.56.2.270].
Ferrarese, C; Sala, G; Riva, R; Begni, B; Zoia, C; Tremolizzo, L; Galimberti, G; Millul, A; Bastone, A; Mennini, T; Balzarini, C; Frattola, L; Beghi, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/15243
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