Background: A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. Methods: To explore the potential moderating effect of these factors, a cross-sectional study was conducted, randomly recruiting subjects with DSM-IV diagnosis of schizophrenia. AUD/SUD was rigorously assessed, as well as COMT Val158Met polymorphism. Executive control functioning was measured using the Intra-Extra Dimensional Set Shift (IED). The effect of a possible interaction between comorbid AUD/SUD and COMT Val158Met polymorphism on IED scores was explored. Results: Subjects with schizophrenia, comorbid AUD/SUD, and MetMet carriers for SNP rs4680 of the COMT gene showed worse performance on IED completed stages scores, as compared with individuals with ValVal genotype. However, among subjects without AUD/SUD, those with the MetMet variant performed better than people carrying ValVal genotype. Conclusions: This study is the first to date examining the impact of COMT on cognition in a highly representative sample of people with schizophrenia and comorbid AUD/SUD. Differential moderating effects of COMT Val/Met genotype variations may similarly influence executive functions in people with schizophrenia and comorbid AUD/SUD.

Carra', G., Nicolini, G., Crocamo, C., Lax, A., Amidani, F., Bartoli, F., et al. (2017). Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders. NORDIC JOURNAL OF PSYCHIATRY, 71(5), 332-339 [10.1080/08039488.2017.1286385].

Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders

CARRA', GIUSEPPE
Primo
;
NICOLINI, GABRIELLA
Secondo
;
CROCAMO, CRISTINA
;
LAX, ANNAMARIA;AMIDANI, FRANCESCA;BARTOLI, FRANCESCO;CASTELLANO, FILIPPO;CHIORAZZI, ALESSIA;GAMBA, GIULIA;PAPAGNO, COSTANZA
Penultimo
;
CLERICI, MASSIMO
Ultimo
2017

Abstract

Background: A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. Methods: To explore the potential moderating effect of these factors, a cross-sectional study was conducted, randomly recruiting subjects with DSM-IV diagnosis of schizophrenia. AUD/SUD was rigorously assessed, as well as COMT Val158Met polymorphism. Executive control functioning was measured using the Intra-Extra Dimensional Set Shift (IED). The effect of a possible interaction between comorbid AUD/SUD and COMT Val158Met polymorphism on IED scores was explored. Results: Subjects with schizophrenia, comorbid AUD/SUD, and MetMet carriers for SNP rs4680 of the COMT gene showed worse performance on IED completed stages scores, as compared with individuals with ValVal genotype. However, among subjects without AUD/SUD, those with the MetMet variant performed better than people carrying ValVal genotype. Conclusions: This study is the first to date examining the impact of COMT on cognition in a highly representative sample of people with schizophrenia and comorbid AUD/SUD. Differential moderating effects of COMT Val/Met genotype variations may similarly influence executive functions in people with schizophrenia and comorbid AUD/SUD.
Articolo in rivista - Articolo scientifico
Dopamine; genetic polymorphism; neuropsychology; schizophrenia; substance dependence; Psychiatry and Mental Health
English
332
339
8
Carra', G., Nicolini, G., Crocamo, C., Lax, A., Amidani, F., Bartoli, F., et al. (2017). Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders. NORDIC JOURNAL OF PSYCHIATRY, 71(5), 332-339 [10.1080/08039488.2017.1286385].
Carra', G; Nicolini, G; Crocamo, C; Lax, A; Amidani, F; Bartoli, F; Castellano, F; Chiorazzi, A; Gamba, G; Papagno, C; Clerici, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/152079
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