ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations. We describe clinical and genomic features of the ERG-related cases in an unselected cohort of B-other BCP ALL pediatric patients enrolled in the AIEOP ALL 2000 therapeutic protocol. We report a small noncoding RNA signature specific of ERG-related group, with up-regulation of miR-125b-2 cluster on chromosome 21 and several snoRNAs in the Prader-Willi locus at 15q11.2, including the orphan SNORD116 cluster.
Vendramini, E., Giordan, M., Giarin, E., Michielotto, B., Fazio, G., Cazzaniga, G., et al. (2017). High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia. ONCOTARGET, 8(26), 42398-42413.
Citazione: | Vendramini, E., Giordan, M., Giarin, E., Michielotto, B., Fazio, G., Cazzaniga, G., et al. (2017). High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia. ONCOTARGET, 8(26), 42398-42413. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | Si |
Titolo: | High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia |
Autori: | Vendramini, E; Giordan, M; Giarin, E; Michielotto, B; Fazio, G; Cazzaniga, G; Biondi, A; Silvestri, D; Valsecchi, M; Muckenthaler, M; Kulozik, A; Gattei, V; Izraeli, S; Basso, G; Te Kronnie, G |
Autori: | |
Data di pubblicazione: | 2017 |
Lingua: | English |
Rivista: | ONCOTARGET |
Digital Object Identifier (DOI): | http://dx.doi.org/10.18632/oncotarget.16392 |
Appare nelle tipologie: | 01 - Articolo su rivista |