DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or nonhomologous end joining (NHEJ). The evolutionarily conserved Mre11-Rad50-Xrs2 (MRX) complex plays a central role in the cellular response to DSBs, as it is implicated in controlling end resection and in maintaining the DSB ends tethered to each other. Furthermore, it is responsible for DSB signaling by activating the checkpoint kinase Tel1 that, in turn, supports MRX function in a positive feedback loop. The present review focuses mainly on recent works in the budding yeast Saccharomyces cerevisiae to highlight structure and regulation of MRX as well as its interplays with Tel1.

GOBBINI, E., CASSANI, C., VILLA, M., BONETTI, D., & LONGHESE, M. (2016). Functions and regulation of the MRX complex at DNA double-strand breaks. MICROBIAL CELL, 3(8), 329-337 [10.15698/mic2016.08.517].

Functions and regulation of the MRX complex at DNA double-strand breaks

GOBBINI, ELISA
Primo
;
CASSANI, CORINNE
Secondo
;
VILLA, MATTEO;BONETTI, DIEGO
Penultimo
;
LONGHESE, MARIA PIA
Ultimo
2016

Abstract

DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or nonhomologous end joining (NHEJ). The evolutionarily conserved Mre11-Rad50-Xrs2 (MRX) complex plays a central role in the cellular response to DSBs, as it is implicated in controlling end resection and in maintaining the DSB ends tethered to each other. Furthermore, it is responsible for DSB signaling by activating the checkpoint kinase Tel1 that, in turn, supports MRX function in a positive feedback loop. The present review focuses mainly on recent works in the budding yeast Saccharomyces cerevisiae to highlight structure and regulation of MRX as well as its interplays with Tel1.
Articolo in rivista - Review Essay
Double-strand break; MRX; Nucleases; Resection; Rif2; Sae2; Tel1;
MRX; Rif2; Sae2; Tel1; double-strand break; nucleases; resection
English
329
337
9
GOBBINI, E., CASSANI, C., VILLA, M., BONETTI, D., & LONGHESE, M. (2016). Functions and regulation of the MRX complex at DNA double-strand breaks. MICROBIAL CELL, 3(8), 329-337 [10.15698/mic2016.08.517].
Gobbini, E; Cassani, C; Villa, M; Bonetti, D; Longhese, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/151596
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