BACKGROUND: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence. CONCLUSIONS: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.

Ferrero, D., Pogliani, E., Rege Cambrin, G., Fava, C., Mattioli, G., Dellacasa, C., et al. (2006). Corticosteroids can reverse severe imatinib-induced hepatotoxicity. HAEMATOLOGICA, 91(6), 78-80.

Corticosteroids can reverse severe imatinib-induced hepatotoxicity

POGLIANI, ENRICO MARIA;
2006

Abstract

BACKGROUND: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence. CONCLUSIONS: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.
Articolo in rivista - Articolo scientifico
Liver Diseases; Prednisone; Antineoplastic Agents; Adrenal Cortex Hormones; Liver; Pyrimidines; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Drug-Induced Liver Injury; Piperazines; Methylprednisolone; Humans
English
2006
91
6
78
80
none
Ferrero, D., Pogliani, E., Rege Cambrin, G., Fava, C., Mattioli, G., Dellacasa, C., et al. (2006). Corticosteroids can reverse severe imatinib-induced hepatotoxicity. HAEMATOLOGICA, 91(6), 78-80.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/15066
Citazioni
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 14
Social impact