The anti-inflammatory effect of the extract of Ruta chalepensis L. (Rutaceae) on the course of lethal endotoxemia in BALB/c mice was studied. When administered by gavage as 1g/kg per day starting 14 or 7 days prior to injection of 0.75mg endotoxin (LPS: lypopolisaccharide), the extract markedly reduced lethality (32.5% in both experiments versus approximately 85% of the control mice). A delay in lethality, but not cumulative lethality, was observed when prophylaxis was given 24 and 1h prior to LPS challenge. The effect was associated with reduced LPS-induced blood levels of nitrite, an indicator of nitric oxide production. In contrast, the blood levels of tumour necrosis factor, interleukin 6 and interleukin 10 did not differ significantly from those of controls given LPS alone. These data show that Ruta Chalepensis L. possesses powerful immunopharmacological properties that make it capable of counteracting the lethal effects of high doses of LPS in vivo. © 2003 Elsevier Ireland Ltd. All rights reserved.

Iauk, L., Mangano, K., Rapisarda, A., Ragusa, S., Maiolino, L., Musumeci, R., et al. (2004). Protection against murine endotoxemia by treatment with Ruta chalepensis L., a plant with anti-inflammatory properties. JOURNAL OF ETHNOPHARMACOLOGY, 90(2-3), 267-272 [10.1016/j.jep.2003.10.004].

Protection against murine endotoxemia by treatment with Ruta chalepensis L., a plant with anti-inflammatory properties

MUSUMECI, ROSARIO;
2004

Abstract

The anti-inflammatory effect of the extract of Ruta chalepensis L. (Rutaceae) on the course of lethal endotoxemia in BALB/c mice was studied. When administered by gavage as 1g/kg per day starting 14 or 7 days prior to injection of 0.75mg endotoxin (LPS: lypopolisaccharide), the extract markedly reduced lethality (32.5% in both experiments versus approximately 85% of the control mice). A delay in lethality, but not cumulative lethality, was observed when prophylaxis was given 24 and 1h prior to LPS challenge. The effect was associated with reduced LPS-induced blood levels of nitrite, an indicator of nitric oxide production. In contrast, the blood levels of tumour necrosis factor, interleukin 6 and interleukin 10 did not differ significantly from those of controls given LPS alone. These data show that Ruta Chalepensis L. possesses powerful immunopharmacological properties that make it capable of counteracting the lethal effects of high doses of LPS in vivo. © 2003 Elsevier Ireland Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
Ruta chalepensis; Endotoxemia; Anti-inflammatory properties
English
267
272
Iauk, L., Mangano, K., Rapisarda, A., Ragusa, S., Maiolino, L., Musumeci, R., et al. (2004). Protection against murine endotoxemia by treatment with Ruta chalepensis L., a plant with anti-inflammatory properties. JOURNAL OF ETHNOPHARMACOLOGY, 90(2-3), 267-272 [10.1016/j.jep.2003.10.004].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14976
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