Previous studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that common chromosome translocations of pediatric leukemia frequently arise before birth. The IGH/TCR clonotypic sequences used as surrogate molecular markers suggest this is also likely to be true for hyperdiploid acute lymphoblastic leukemia (ALL). Yet evidence that hyperdiploidy itself is an early or initiating event occurring prenatally has been limited. Now, however, we can provide direct evidence of this from our identification of CD34+/CD19+ B-lineage progenitor cells with triploid chromosomes in the stored cord blood of an individual who subsequently developed hyperdiploid ALL.

Maia, A., Tussiwand, R., Cazzaniga, G., Rebulla, P., Colman, S., Biondi, A., et al. (2004). Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood. GENES, CHROMOSOMES & CANCER, 40(1), 38-43 [10.1002/gcc.20010].

Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood

Cazzaniga, G;BIONDI, ANDREA;
2004

Abstract

Previous studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that common chromosome translocations of pediatric leukemia frequently arise before birth. The IGH/TCR clonotypic sequences used as surrogate molecular markers suggest this is also likely to be true for hyperdiploid acute lymphoblastic leukemia (ALL). Yet evidence that hyperdiploidy itself is an early or initiating event occurring prenatally has been limited. Now, however, we can provide direct evidence of this from our identification of CD34+/CD19+ B-lineage progenitor cells with triploid chromosomes in the stored cord blood of an individual who subsequently developed hyperdiploid ALL.
Articolo in rivista - Articolo scientifico
HLA-DR Antigens; Male; Polyploidy; Antigens, CD19; Infant; Female; Child, Preschool; Karyotyping; B-Lymphocytes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Humans; Stem Cells; Fetal Blood; Child; Antigens, CD34; Preleukemia
English
38
43
Maia, A., Tussiwand, R., Cazzaniga, G., Rebulla, P., Colman, S., Biondi, A., et al. (2004). Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood. GENES, CHROMOSOMES & CANCER, 40(1), 38-43 [10.1002/gcc.20010].
Maia, A; Tussiwand, R; Cazzaniga, G; Rebulla, P; Colman, S; Biondi, A; Greaves, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14887
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