The formulation of quinic acid, a food constituent demonstrating potential anticaries and antigingivitis properties, was investigated in an adhesive microparticulate delivery system with the goal of improving its effect by prolonging its residence time at the site of action. Alginate and chitosan were selected as mucoadhesive polymers. The microspheres were prepared by coacervation. Different types of alginates, polymers blends and crosslinking agent concentrations were considered and evaluated. The best results in terms of encapsulation efficiency, in vitro active agent release profile and in vitro adhesive properties, both to oral mucosa and to teeth surface, were obtained with a blend of Alginate Protanal LF200S: Alginate Protanal LF120LS 1:1.5 w/w, 0.1 M CaCl2, and chitosan coating, prepared by a one-step complex coacervation method. This microparticulate delivery system showed prolonged release of quinic acid, and could be used as an active component in chewing gums or mouthwashes for both caries and gingivitis prevention. © 2012 Elsevier Ltd. All rights reserved

Conti, B., Colzani, B., Papetti, A., Mascherpa, D., Dorati, R., Genta, I., et al. (2013). Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin. FOOD CHEMISTRY, 138(2-3), 898-904 [10.1016/j.foodchem.2012.11.097].

Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin

COLZANI, BARBARA
Secondo
;
2013

Abstract

The formulation of quinic acid, a food constituent demonstrating potential anticaries and antigingivitis properties, was investigated in an adhesive microparticulate delivery system with the goal of improving its effect by prolonging its residence time at the site of action. Alginate and chitosan were selected as mucoadhesive polymers. The microspheres were prepared by coacervation. Different types of alginates, polymers blends and crosslinking agent concentrations were considered and evaluated. The best results in terms of encapsulation efficiency, in vitro active agent release profile and in vitro adhesive properties, both to oral mucosa and to teeth surface, were obtained with a blend of Alginate Protanal LF200S: Alginate Protanal LF120LS 1:1.5 w/w, 0.1 M CaCl2, and chitosan coating, prepared by a one-step complex coacervation method. This microparticulate delivery system showed prolonged release of quinic acid, and could be used as an active component in chewing gums or mouthwashes for both caries and gingivitis prevention. © 2012 Elsevier Ltd. All rights reserved
Articolo in rivista - Articolo scientifico
Alginate; Anticaries; Antigingivitis; Bioadhesion; Chitosan; Functional foods; Microparticles; Alginates; Cariostatic Agents; Chitosan; Drug Carriers; Drug Delivery Systems; Humans; Microspheres; Plant Extracts; Quinic Acid; Vegetables; Analytical Chemistry; Food Science
English
898
904
7
Conti, B., Colzani, B., Papetti, A., Mascherpa, D., Dorati, R., Genta, I., et al. (2013). Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin. FOOD CHEMISTRY, 138(2-3), 898-904 [10.1016/j.foodchem.2012.11.097].
Conti, B; Colzani, B; Papetti, A; Mascherpa, D; Dorati, R; Genta, I; Pruzzo, C; Signoretto, C; Zaura, E; Lingström, P; Ofek, I; Wilson, M; Spratt, D; Gazzani, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/147778
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