A stability study was performed on ivermectin (IVM)-loaded biodegradable microparticles intended for injection in dogs. The rational was to evaluate the performances upon irradiation of a drug, such as IVM, with a few criticalities with respect to its stability, and toxicity. The goal was to provide valuable information for pharmaceutical scientists and manufacturers working in the veterinary area. The microspheres based on poly(D,L-lactide) and poly-(ε-caprolactone) and loaded with IVM and with the addition of alpha-tocopherol (TCP) as antioxidant were prepared by the emulsion solvent evaporation method and sterilized by gamma irradiation. Microsphere characterization in term of size, shape, polymer, and IVM stability upon irradiation was performed. The results show that the type of polymer significantly affects microsphere characteristics and performances. Moreover, suitably stable formulations can be achieved only by TCP addition.

Dorati, R., Genta, I., Colzani, B., Modena, T., Bruni, G., Tripodo, G., et al. (2015). Stability Evaluation of Ivermectin-Loaded Biodegradable Microspheres. AAPS PHARMSCITECH, 16(5), 1129-1139 [10.1208/s12249-015-0305-1].

Stability Evaluation of Ivermectin-Loaded Biodegradable Microspheres

COLZANI, BARBARA;
2015

Abstract

A stability study was performed on ivermectin (IVM)-loaded biodegradable microparticles intended for injection in dogs. The rational was to evaluate the performances upon irradiation of a drug, such as IVM, with a few criticalities with respect to its stability, and toxicity. The goal was to provide valuable information for pharmaceutical scientists and manufacturers working in the veterinary area. The microspheres based on poly(D,L-lactide) and poly-(ε-caprolactone) and loaded with IVM and with the addition of alpha-tocopherol (TCP) as antioxidant were prepared by the emulsion solvent evaporation method and sterilized by gamma irradiation. Microsphere characterization in term of size, shape, polymer, and IVM stability upon irradiation was performed. The results show that the type of polymer significantly affects microsphere characteristics and performances. Moreover, suitably stable formulations can be achieved only by TCP addition.
Articolo in rivista - Articolo scientifico
alpha-tocopherol; gamma irradiation; ivermectin; microspheres; poly(D,L-lactide); poly-(ε-caprolactone); Antioxidants; Antiparasitic Agents; Drug Compounding; Drug Stability; Excipients; Gamma Rays; Ivermectin; Microspheres; Models, Chemical; Polyesters; Solubility; Veterinary Drugs; alpha-Tocopherol; Drug Carriers; 3003
English
1129
1139
11
Dorati, R., Genta, I., Colzani, B., Modena, T., Bruni, G., Tripodo, G., et al. (2015). Stability Evaluation of Ivermectin-Loaded Biodegradable Microspheres. AAPS PHARMSCITECH, 16(5), 1129-1139 [10.1208/s12249-015-0305-1].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/147730
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