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C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported. © 2007 Elsevier Ltd. All rights reserved.

Podlipnik, C., Velter, I., LA FERLA, B., Marcou, G., Belvisi, L., Nicotra, F., et al. (2007). First round of focused library for cholera toxin inhibitor search. CARBOHYDRATE RESEARCH, 342(12/13), 1651-1660 [10.1016/j.carres.2007.06.006].

First round of focused library for cholera toxin inhibitor search

LA FERLA, BARBARA;NICOTRA, FRANCESCO;
2007

Abstract

C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported. © 2007 Elsevier Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
C-Glycosides; Carbohydrate mimics; Cholera toxin; Glycomimetics; GM1 ganglioside
English
2007
342
12/13
1651
1660
none
Podlipnik, C., Velter, I., LA FERLA, B., Marcou, G., Belvisi, L., Nicotra, F., et al. (2007). First round of focused library for cholera toxin inhibitor search. CARBOHYDRATE RESEARCH, 342(12/13), 1651-1660 [10.1016/j.carres.2007.06.006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14661
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