The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

Vescovi, A., Galli, R., Reynolds, B. (2006). Brain tumour stem cells. NATURE REVIEWS CANCER, 6(6), 425-436 [10.1038/nrc1889].

Brain tumour stem cells

VESCOVI, ANGELO LUIGI;
2006

Abstract

The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
Articolo in rivista - Articolo scientifico
Central Nervous System Neoplasms; Neoplastic Stem Cells; Neurons; Models, Biological; Brain Neoplasms; Brain; Animals; Humans
English
2006
6
6
425
436
none
Vescovi, A., Galli, R., Reynolds, B. (2006). Brain tumour stem cells. NATURE REVIEWS CANCER, 6(6), 425-436 [10.1038/nrc1889].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14632
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