The cell envelope of Gram-negative bacteria consists of two distinct membranes, the inner (IM) and the outer membrane (OM) separated by the periplasm. The OM contains in the outer leaflet the lipopolysaccharide (LPS), a complex lipid with important biological activities. In the host it elicits the innate immune response whereas in the bacterium it is responsible for the peculiar permeability barrier properties exhibited by the OM. The chemical structure of LPS and its biosynthetic pathways have been fully elucidated. By contrast only recently details of the transport and assembly of LPS into the OM have emerged. LPS is synthesized in the cytoplasm and at the inner leaflet of the IM and needs to cross two different compartments, the IM and the periplasm, to reach its final destination at the OM. This review focuses on recent studies that led to our present understanding of the protein machine implicated in LIPS transport and in assembly at the cell surface

Sperandeo, P., Deho, G., Polissi, A. (2009). The lipopolysaccharide transport system of Gram-negative bacteria. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1791(7), 594-602 [10.1016/j.bbalip.2009.01.011].

The lipopolysaccharide transport system of Gram-negative bacteria

Sperandeo, P;Polissi, A
2009

Abstract

The cell envelope of Gram-negative bacteria consists of two distinct membranes, the inner (IM) and the outer membrane (OM) separated by the periplasm. The OM contains in the outer leaflet the lipopolysaccharide (LPS), a complex lipid with important biological activities. In the host it elicits the innate immune response whereas in the bacterium it is responsible for the peculiar permeability barrier properties exhibited by the OM. The chemical structure of LPS and its biosynthetic pathways have been fully elucidated. By contrast only recently details of the transport and assembly of LPS into the OM have emerged. LPS is synthesized in the cytoplasm and at the inner leaflet of the IM and needs to cross two different compartments, the IM and the periplasm, to reach its final destination at the OM. This review focuses on recent studies that led to our present understanding of the protein machine implicated in LIPS transport and in assembly at the cell surface
Articolo in rivista - Articolo scientifico
Bacterial envelope; Outer membrane biogenesis; Lipopolysac transport; Endotoxin
Lipopolisaccaride, microbiologia
English
594
602
9
Sperandeo, P., Deho, G., Polissi, A. (2009). The lipopolysaccharide transport system of Gram-negative bacteria. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1791(7), 594-602 [10.1016/j.bbalip.2009.01.011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14520
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