Dendritic cells (DCs) play a critical role in orchestrating the innate and adaptive components of the immune system so that appropriate, coordinated responses are mounted against infectious agents. Tissue-resident DCs interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Antigens use PRR activation to instruct DCs for the appropriate priming of natural killer (NK) cells, followed by specific T-cell responses. Due to the central role of DCs in regulating the activation and progression of immune responses, minor imbalances in the feedback control of Toll-like receptor (TLR)-activated cells have been associated with autoimmunity in genetically prone individuals. We review here recent findings on the role of DCs in the priming of innate and adaptive immune responses and the possible involvement of DCs in inducing and maintaining autoimmune reactions.

Granucci, F., Zanoni, I., Castagnoli, P. (2008). Central role of dendritic cells in the regulation and deregulation of immune responses. CELLULAR AND MOLECULAR LIFE SCIENCES, 65(11), 1683-1697 [10.1007/s00018-008-8009-2].

Central role of dendritic cells in the regulation and deregulation of immune responses

GRANUCCI, FRANCESCA;ZANONI, IVAN;CASTAGNOLI, PAOLA
2008

Abstract

Dendritic cells (DCs) play a critical role in orchestrating the innate and adaptive components of the immune system so that appropriate, coordinated responses are mounted against infectious agents. Tissue-resident DCs interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Antigens use PRR activation to instruct DCs for the appropriate priming of natural killer (NK) cells, followed by specific T-cell responses. Due to the central role of DCs in regulating the activation and progression of immune responses, minor imbalances in the feedback control of Toll-like receptor (TLR)-activated cells have been associated with autoimmunity in genetically prone individuals. We review here recent findings on the role of DCs in the priming of innate and adaptive immune responses and the possible involvement of DCs in inducing and maintaining autoimmune reactions.
Articolo in rivista - Review Essay
Adaptive immunity; Autoimmunity; CD14; Dendritic cells; Innate immunity; Natural killer cells; Pattern recognition receptors;
English
2008
65
11
1683
1697
reserved
Granucci, F., Zanoni, I., Castagnoli, P. (2008). Central role of dendritic cells in the regulation and deregulation of immune responses. CELLULAR AND MOLECULAR LIFE SCIENCES, 65(11), 1683-1697 [10.1007/s00018-008-8009-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14474
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