Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interuption and therapeutic applications will be reviewed. © 2006 Bentham Science Publishers Ltd.
Redaelli, C., Granucci, F., DE GIOIA, L., Cipolla, L. (2006). Synthesis and biological activity of AkT/PI3K inhibitors. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 6(10), 1127-1136 [10.2174/138955706778560139].
Synthesis and biological activity of AkT/PI3K inhibitors
GRANUCCI, FRANCESCA;DE GIOIA, LUCA;CIPOLLA, LAURA FRANCESCA
2006
Abstract
Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interuption and therapeutic applications will be reviewed. © 2006 Bentham Science Publishers Ltd.
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