Purpose Design, realization, scan, and characterization of a phantom for PET Automatic Segmentation (PET-AS) assessment are presented. Radioactive zeolites immersed in a radioactive heterogeneous background simulate realistic wall-less lesions with known irregular shape and known homogeneous or heterogeneous internal activity. Method Three different zeolite families were evaluated in terms of radioactive uptake homogeneity, necessary to define activity and contour ground truth. Heterogeneous lesions were simulated by the perfect matching of two portions of a broken zeolite, soaked in two different 18F-FDG radioactive solutions. Heterogeneous backgrounds were obtained with tissue paper balls and sponge pieces immersed into radioactive solutions. Results Natural clinoptilolite proved to be the most suitable zeolite for the construction of artificial objects mimicking homogeneous and heterogeneous uptakes in 18F-FDG PET lesions. Heterogeneous backgrounds showed a coefficient of variation equal to 269% and 443% of a uniform radioactive solution. Assembled phantom included eight lesions with volumes ranging from 1.86 to 7.24 ml and lesion to background contrasts ranging from 4.8:1 to 21.7:1. Conclusions A novel phantom for the evaluation of PET-AS algorithms was developed. It is provided with both reference contours and activity ground truth, and it covers a wide range of volumes and lesion to background contrasts. The dataset is open to the community of PET-AS developers and utilizers.

Soffientini, C., DE BERNARDI, E., Casati, R., Baselli, G., Zito, F. (2017). Technical Note: A new zeolite PET phantom to test segmentation algorithms on heterogeneous activity distributions featured with ground-truth contours. MEDICAL PHYSICS, 44(1), 221-226 [10.1002/mp.12014].

Technical Note: A new zeolite PET phantom to test segmentation algorithms on heterogeneous activity distributions featured with ground-truth contours

DE BERNARDI, ELISABETTA
Secondo
;
2017

Abstract

Purpose Design, realization, scan, and characterization of a phantom for PET Automatic Segmentation (PET-AS) assessment are presented. Radioactive zeolites immersed in a radioactive heterogeneous background simulate realistic wall-less lesions with known irregular shape and known homogeneous or heterogeneous internal activity. Method Three different zeolite families were evaluated in terms of radioactive uptake homogeneity, necessary to define activity and contour ground truth. Heterogeneous lesions were simulated by the perfect matching of two portions of a broken zeolite, soaked in two different 18F-FDG radioactive solutions. Heterogeneous backgrounds were obtained with tissue paper balls and sponge pieces immersed into radioactive solutions. Results Natural clinoptilolite proved to be the most suitable zeolite for the construction of artificial objects mimicking homogeneous and heterogeneous uptakes in 18F-FDG PET lesions. Heterogeneous backgrounds showed a coefficient of variation equal to 269% and 443% of a uniform radioactive solution. Assembled phantom included eight lesions with volumes ranging from 1.86 to 7.24 ml and lesion to background contrasts ranging from 4.8:1 to 21.7:1. Conclusions A novel phantom for the evaluation of PET-AS algorithms was developed. It is provided with both reference contours and activity ground truth, and it covers a wide range of volumes and lesion to background contrasts. The dataset is open to the community of PET-AS developers and utilizers.
Articolo in rivista - Articolo scientifico
18F-FDG PET; experimental phantoms; segmentation; zeolites
English
221
226
6
Soffientini, C., DE BERNARDI, E., Casati, R., Baselli, G., Zito, F. (2017). Technical Note: A new zeolite PET phantom to test segmentation algorithms on heterogeneous activity distributions featured with ground-truth contours. MEDICAL PHYSICS, 44(1), 221-226 [10.1002/mp.12014].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/142704
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