Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a ‘one size fits all’ approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future.
Carbone, M., Ronca, V., Bruno, S., Invernizzi, P., & Mells, G. (2016). Toward precision medicine in primary biliary cholangitis. DIGESTIVE AND LIVER DISEASE, 48(8), 843-850.
Citazione: | Carbone, M., Ronca, V., Bruno, S., Invernizzi, P., & Mells, G. (2016). Toward precision medicine in primary biliary cholangitis. DIGESTIVE AND LIVER DISEASE, 48(8), 843-850. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | Si |
Titolo: | Toward precision medicine in primary biliary cholangitis |
Autori: | Carbone, M; Ronca, V; Bruno, S; Invernizzi, P; Mells, G |
Autori: | INVERNIZZI, PIETRO (Penultimo) |
Data di pubblicazione: | 2016 |
Lingua: | English |
Rivista: | DIGESTIVE AND LIVER DISEASE |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.dld.2016.05.023 |
Appare nelle tipologie: | 01 - Articolo su rivista |