Cerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several methods may be used for assessing cerebral collaterals in the acute phase of ischemic stroke in humans and rodents, they are generally underutilized. Experimental stroke models may play a unique role in understanding the adaptive response of cerebral collaterals during ischemia and their potential for therapeutic modulation. The systematic assessment of collateral perfusion in experimental stroke models may be used as a "stratification factor" in multiple regression analysis of neuroprotection studies, in order to control the within-group variability. Exploring the modulatory mechanisms of cerebral collaterals in stroke models may promote the translational development of therapeutic strategies for increasing collateral flow and directly compare them in term of efficacy, safety and feasibility. Collateral therapeutics may have a role in the hyperacute (even pre-hospital) phase of ischemic stroke, prior to recanalization therapies.

Cuccione, E., Padovano, G., Versace, A., Ferrarese, C., Beretta, S. (2016). Cerebral collateral circulation in experimental ischemic stroke. EXPERIMENTAL & TRANSLATIONAL STROKE MEDICINE, 8(1) [10.1186/s13231-016-0015-0].

Cerebral collateral circulation in experimental ischemic stroke

CUCCIONE, ELISA
Primo
;
PADOVANO, GIADA
Secondo
;
FERRARESE, CARLO
Penultimo
;
2016

Abstract

Cerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several methods may be used for assessing cerebral collaterals in the acute phase of ischemic stroke in humans and rodents, they are generally underutilized. Experimental stroke models may play a unique role in understanding the adaptive response of cerebral collaterals during ischemia and their potential for therapeutic modulation. The systematic assessment of collateral perfusion in experimental stroke models may be used as a "stratification factor" in multiple regression analysis of neuroprotection studies, in order to control the within-group variability. Exploring the modulatory mechanisms of cerebral collaterals in stroke models may promote the translational development of therapeutic strategies for increasing collateral flow and directly compare them in term of efficacy, safety and feasibility. Collateral therapeutics may have a role in the hyperacute (even pre-hospital) phase of ischemic stroke, prior to recanalization therapies.
Articolo in rivista - Review Essay
Cerebral collaterals; Collateral therapeutics; Experimental stroke models; Infarct size variability; Ischemic penumbra; Ischemic stroke;
English
Cuccione, E., Padovano, G., Versace, A., Ferrarese, C., Beretta, S. (2016). Cerebral collateral circulation in experimental ischemic stroke. EXPERIMENTAL & TRANSLATIONAL STROKE MEDICINE, 8(1) [10.1186/s13231-016-0015-0].
Cuccione, E; Padovano, G; Versace, A; Ferrarese, C; Beretta, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/141110
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