Alterations in peripheral blood lymphocyte subpopulations have been demonstrated in many diseases in which plasmapheresis, together with glucocorticosteroids or other immunosuppressive drugs, are therapeutic alternatives. To investigate apheresis-induced modifications, lymphocyte subsets were monitored in eight patients receiving such treatment, with particular attention to changes in OKT4/T8 (helper/suppressor) ratios. The results suggest the possibility that treatment-induced changes in peripheral blood lymphocyte subpopulations are responsible for a normalization of the T4/T8 ratio in patients with abnormal starting values.
Fiorini, G., Paracchini, M., Fornasieri, A., Sinico, R., Colasanti, G., Gibelli, A., et al. (1982). Modifications in peripheral-blood lymphocyte subpopulations induced by plasmapheresis and immunosuppressive drugs. PLASMA THERAPY & TRANSFUSION TECHNOLOGY, 3(4), 389-393.
Modifications in peripheral-blood lymphocyte subpopulations induced by plasmapheresis and immunosuppressive drugs
SINICO, RENATO ALBERTO;
1982
Abstract
Alterations in peripheral blood lymphocyte subpopulations have been demonstrated in many diseases in which plasmapheresis, together with glucocorticosteroids or other immunosuppressive drugs, are therapeutic alternatives. To investigate apheresis-induced modifications, lymphocyte subsets were monitored in eight patients receiving such treatment, with particular attention to changes in OKT4/T8 (helper/suppressor) ratios. The results suggest the possibility that treatment-induced changes in peripheral blood lymphocyte subpopulations are responsible for a normalization of the T4/T8 ratio in patients with abnormal starting values.
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