Objective To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection. Methods We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. Conclusions New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

Puoti, M., Lorenzini, P., Cozzi Lepri, A., Gori, A., Mastroianni, C., Rizzardini, G., et al. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. CLINICAL MICROBIOLOGY AND INFECTION, 23(4), 267-267.e4 [10.1016/j.cmi.2016.12.003].

Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

Puoti, M;GORI, ANDREA;
2017

Abstract

Objective To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection. Methods We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. Conclusions New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.
Articolo in rivista - Articolo scientifico
Cirrhosis; Cohort study; Hepatitis C virus; Human immunodeficiency virus; Incidence;
Cirrhosis; Cohort study; Hepatitis C virus; Human immunodeficiency virus; Incidence
English
267
267.e4
Puoti, M., Lorenzini, P., Cozzi Lepri, A., Gori, A., Mastroianni, C., Rizzardini, G., et al. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. CLINICAL MICROBIOLOGY AND INFECTION, 23(4), 267-267.e4 [10.1016/j.cmi.2016.12.003].
Puoti, M; Lorenzini, P; Cozzi Lepri, A; Gori, A; Mastroianni, C; Rizzardini, G; Mazzarello, G; Antinori, A; d'Arminio Monforte, A; Girardi, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140844
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