Purpose: This study aims to systematically review studies quantifying the associations between antidepressants (ADs) use and the risk of cardiovascular (CV) outcomes. Methods: Medline was searched to October 2015 for full text articles in English. Prospective cohort and case-control studies were admitted if they investigated the relationship between current use of ADs as a whole, tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs), and the onset CV events. Summary relative risks (RRs) with confidence intervals (CIs) were calculated using random-effects or fixed-effects models. Results: A total of 99,367 incident cases of CV outcomes who met inclusion criteria were identified from 22 observational studies. Compared with no users of ADs, use of SSRIs was associated with an increased risk of cerebrovascular disease (RRs, 1.24; 95% CI, 1.15 to 1.34), while the use of TCA was associated with an increased risk of acute heart disease (RRs, 1.29; 95% CI, 1.09 to 1.54). Conclusions: The results of this meta-analysis have to be taken with caution because even though an increased risk of cerebrovascular and acute heart disease was observed respectively in SSRIs and TCA users, the estimates are characterized by a high between study heterogeneity. Moreover, it was not possible to distinguish between the effects of ADs and depression itself. Further well-designed studies are required to confirm this association

Biffi, A., Scotti, L., Corrao, G. (2017). Use of antidepressants and the risk of cardiovascular and cerebrovascular disease: a meta-analysis of observational studies. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 73(4), 487-497 [10.1007/s00228-016-2187-x].

Use of antidepressants and the risk of cardiovascular and cerebrovascular disease: a meta-analysis of observational studies

BIFFI, ANNALISA
Primo
;
SCOTTI, LORENZA
Secondo
;
CORRAO, GIOVANNI
Ultimo
2017

Abstract

Purpose: This study aims to systematically review studies quantifying the associations between antidepressants (ADs) use and the risk of cardiovascular (CV) outcomes. Methods: Medline was searched to October 2015 for full text articles in English. Prospective cohort and case-control studies were admitted if they investigated the relationship between current use of ADs as a whole, tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs), and the onset CV events. Summary relative risks (RRs) with confidence intervals (CIs) were calculated using random-effects or fixed-effects models. Results: A total of 99,367 incident cases of CV outcomes who met inclusion criteria were identified from 22 observational studies. Compared with no users of ADs, use of SSRIs was associated with an increased risk of cerebrovascular disease (RRs, 1.24; 95% CI, 1.15 to 1.34), while the use of TCA was associated with an increased risk of acute heart disease (RRs, 1.29; 95% CI, 1.09 to 1.54). Conclusions: The results of this meta-analysis have to be taken with caution because even though an increased risk of cerebrovascular and acute heart disease was observed respectively in SSRIs and TCA users, the estimates are characterized by a high between study heterogeneity. Moreover, it was not possible to distinguish between the effects of ADs and depression itself. Further well-designed studies are required to confirm this association
Articolo in rivista - Articolo scientifico
Antidepressants; Cardiovascular disease; Cerebrovascular disease; Depression; Selective serotonin reuptake inhibitors; Stroke; Tricyclic antidepressants;
English
2017
73
4
487
497
reserved
Biffi, A., Scotti, L., Corrao, G. (2017). Use of antidepressants and the risk of cardiovascular and cerebrovascular disease: a meta-analysis of observational studies. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 73(4), 487-497 [10.1007/s00228-016-2187-x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140459
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