Background. The predictive value of clinical and renal histological features for renal outcome in patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis was investigated in a prospective analysis of 96 patients with ANCA-associated vasculitis, and moderate renal involvement (creatinine <500 μmol/L). Methods. The extent of 39 histological features in 96 biopsies (performed at entry in a clinical trial) was scored by two independent observers, according to a standardized protocol. Age, gender, diagnosis, glomerular filtration rate at entry (GFR0), ANCA-specificity, proteinuria, and treatment of these 96 patients were also taken into account. Treatment was standardized and started after the biopsy was performed. Endpoints included renal function at 18 months (GFR18), GFR18 corrected for GFR0 (CORGFR18), and the occurrence of relapse or death. Results. Parameters that most strongly correlated with GFR18 were GFR0 (r = 0.67), interstitial fibrosis (r = -0.45), glomerulosclerosis (r = -0.37), and tubular atrophy (r = -0.36). Parameters that most strongly correlated with CORGFR18 were segmental (r = 0.45) and cellular (r = 0.30) crescents, and fibrinoid necrosis (r = 0.46). None of the clinical and histological features predicted the occurrence of relapse or death. By applying a stepwise linear multiple regression analysis, we designed a formula for the estimation of renal function at 18 months: GFR18 (mL/min) = 17 + 0.71 × GFR0 (mL/min) + 0.34 × fibrinoid necrosis (%) + 0.33 × segmental crescents (%), (r2 = 0.60; standard deviation = 19 mL/min). Our results were independent of diagnosis, ANCA-specificity, and treatment limb. Conclusions. These data suggest that in ANCA-associated glomerulonephritis, GFR0 and predominantly chronic renal lesions are potent predictors of GFR18. Active lesions are associated with renal function recovery and may be reversible. The formula for the estimation of GFR18 shows that a combination of GFR0 and renal histology is a better predictor for GFR18 than GFR0 only.

Hauer, H., Bajema, I., Van Houwelingen, H., Ferrario, F., Noël, L., Waldherr, R., et al. (2002). Clinical nephrology-epidemiology-clinical trials: Determinants of outcome in ANCA-associated glomerulonephritis: A prospective clinico-histopathological analysis of 96 patients. KIDNEY INTERNATIONAL, 62(5), 1732-1742 [10.1046/j.1523-1755.2002.00605.x].

Clinical nephrology-epidemiology-clinical trials: Determinants of outcome in ANCA-associated glomerulonephritis: A prospective clinico-histopathological analysis of 96 patients

SINICO, RENATO ALBERTO;
2002

Abstract

Background. The predictive value of clinical and renal histological features for renal outcome in patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis was investigated in a prospective analysis of 96 patients with ANCA-associated vasculitis, and moderate renal involvement (creatinine <500 μmol/L). Methods. The extent of 39 histological features in 96 biopsies (performed at entry in a clinical trial) was scored by two independent observers, according to a standardized protocol. Age, gender, diagnosis, glomerular filtration rate at entry (GFR0), ANCA-specificity, proteinuria, and treatment of these 96 patients were also taken into account. Treatment was standardized and started after the biopsy was performed. Endpoints included renal function at 18 months (GFR18), GFR18 corrected for GFR0 (CORGFR18), and the occurrence of relapse or death. Results. Parameters that most strongly correlated with GFR18 were GFR0 (r = 0.67), interstitial fibrosis (r = -0.45), glomerulosclerosis (r = -0.37), and tubular atrophy (r = -0.36). Parameters that most strongly correlated with CORGFR18 were segmental (r = 0.45) and cellular (r = 0.30) crescents, and fibrinoid necrosis (r = 0.46). None of the clinical and histological features predicted the occurrence of relapse or death. By applying a stepwise linear multiple regression analysis, we designed a formula for the estimation of renal function at 18 months: GFR18 (mL/min) = 17 + 0.71 × GFR0 (mL/min) + 0.34 × fibrinoid necrosis (%) + 0.33 × segmental crescents (%), (r2 = 0.60; standard deviation = 19 mL/min). Our results were independent of diagnosis, ANCA-specificity, and treatment limb. Conclusions. These data suggest that in ANCA-associated glomerulonephritis, GFR0 and predominantly chronic renal lesions are potent predictors of GFR18. Active lesions are associated with renal function recovery and may be reversible. The formula for the estimation of GFR18 shows that a combination of GFR0 and renal histology is a better predictor for GFR18 than GFR0 only.
Articolo in rivista - Articolo scientifico
ANCA-associated vasculitis; Microscopic polyangiitis; Pauci-immune crescentic necrotizing glomerulonephritis; Renal biopsy; Wegener's granulomatosis; Antibodies, Antineutrophil Cytoplasmic; Azathioprine; Biopsy; Cyclophosphamide; Glomerular Filtration Rate; Glomerulonephritis; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Predictive Value of Tests; Prognosis; Prospective Studies; Recurrence; Sample Size; Treatment Outcome; Medicine (all); Nephrology
English
1732
1742
11
Hauer, H., Bajema, I., Van Houwelingen, H., Ferrario, F., Noël, L., Waldherr, R., et al. (2002). Clinical nephrology-epidemiology-clinical trials: Determinants of outcome in ANCA-associated glomerulonephritis: A prospective clinico-histopathological analysis of 96 patients. KIDNEY INTERNATIONAL, 62(5), 1732-1742 [10.1046/j.1523-1755.2002.00605.x].
Hauer, H; Bajema, I; Van Houwelingen, H; Ferrario, F; Noël, L; Waldherr, R; Jayne, D; Rasmussen, N; Bruijn, J; Hagen, E; Rasmussen, N; Jayne, D; Neumann, I; Mad Houn, P; Sennesael, J; Tesar, V; Rychlik, I; Bartunkova, J; Luk, J; Juhl, B; Petersen, J; Andersen, C; Szpirt, W; Wiik, A; Lokkegaard, H; Nielsen, H; Ring, T; Sorensen, S; Bacon, P; Exley, A; Savage, C; Gaskin, G; Pusey, C; Lockwood, C; Luq Mani, R; Gronhagen Riska, C; Ekstrand, A; Guillevin, L; Lhote, F; Lesavre, P; Noel, L; Landais, P; Vanhille, P; Bataille, P; Esnault, V; Woude, F; Waldherr, R; Schmitt, W; Andrassy, K; Hergesell, O; Nowack, R; Groot, K; Herlyn, K; Gross, W; Boki, K; Boletis, J; Emmanouel, D; Feighery, C; Ferra Rio, Y; Sinico, R; Gregorini, G; Dadoniene, J; Hagen, E; Kallenberg, C; Stegeman, C; Tervaert, J; Verburgh, C; Siegert, C; Bruijn, J; Hauer, H; Hermans, J; Houwelingen, J; Vergunst, C; Gurp, E; Bajema, I; Vasconcelos, C; Mirapeix, E; Sole, M; Petterson, E; Bruchfeld, A; Westman, K; Heigl, Z; Chizzolini, C; Maclahan, D; Depierreux, M; van Damme, B; Stejskalova, A; Vernerova, Z; Tornroth, T; Feller, A; Gaffney, E; Tardanico, R; Consalonieri, R; Garibotto, G; Tiebosch, A; Kooijman, C; Arques, M; Algaba, F; Carreras, M; Perez, M; Bernardo, L; Sundelin, B; Alm, P; Wernersson, A; Veress, B; Landells, W; Howie, A; Fleming, S; Griffith, A; Furness, P; Cook, H
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140386
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