Circulating IgA-antigliadin antibodies were detected with enzyme linked immunosorbent assay (ELISA) in four of 121 patients (3%) who had IgA mesangial nephropathy and 14 of 17 children (82%) who had untreated coeliac disease. No positive cases were present in the 54 healthy subjects of the control group. Three patients who had IgA nephropathy and IgA-antigliadin antibodies underwent jejunal biopsy, and two showed mucosal atrophy. In these two patients urinary abnormalities, together with the IgA-antigliadin antibodies, disappeared completely after three months and five months, respectively, of following a gluten free diet. Circulating IgA immune complexes were found in most patients who had coeliac disease and Berger's disease associated with IgA-antigliadin antibodies, suggesting overactivity of the B cells producing IgA in both conditions. By contrast, a circulating IgA rheumatoid factor was detectable in three of the four patients who had IgA nephropathy and asymptomatic coeliac disease but was always absent in children who had coeliac disease but did not show signs of renal disease. These results suggest that a more complex abnormality in the IgA immune response is necessary for renal disease to become manifest in patients who have gluten enteropathy.

Fornasieri, A., Sinico, R., Maldifassi, P., Bernasconi, P., Vegni, M., D'Amico, G. (1987). IgA-antigliadin antibodies in IgA mesangial nephropathy (Berger's disease). BRITISH MEDICAL JOURNAL, 295(6590), 78-80 [10.1136/bmj.295.6590.78].

IgA-antigliadin antibodies in IgA mesangial nephropathy (Berger's disease)

SINICO, RENATO ALBERTO
Secondo
;
1987

Abstract

Circulating IgA-antigliadin antibodies were detected with enzyme linked immunosorbent assay (ELISA) in four of 121 patients (3%) who had IgA mesangial nephropathy and 14 of 17 children (82%) who had untreated coeliac disease. No positive cases were present in the 54 healthy subjects of the control group. Three patients who had IgA nephropathy and IgA-antigliadin antibodies underwent jejunal biopsy, and two showed mucosal atrophy. In these two patients urinary abnormalities, together with the IgA-antigliadin antibodies, disappeared completely after three months and five months, respectively, of following a gluten free diet. Circulating IgA immune complexes were found in most patients who had coeliac disease and Berger's disease associated with IgA-antigliadin antibodies, suggesting overactivity of the B cells producing IgA in both conditions. By contrast, a circulating IgA rheumatoid factor was detectable in three of the four patients who had IgA nephropathy and asymptomatic coeliac disease but was always absent in children who had coeliac disease but did not show signs of renal disease. These results suggest that a more complex abnormality in the IgA immune response is necessary for renal disease to become manifest in patients who have gluten enteropathy.
Articolo in rivista - Articolo scientifico
Adolescent; Adult; Aged; Antigen-Antibody Complex; Celiac Disease; Child; Female; Gliadin; Glomerulonephritis, IGA; Humans; Immunoglobulin A; Male; Middle Aged; Plant Proteins
English
78
80
3
Fornasieri, A., Sinico, R., Maldifassi, P., Bernasconi, P., Vegni, M., D'Amico, G. (1987). IgA-antigliadin antibodies in IgA mesangial nephropathy (Berger's disease). BRITISH MEDICAL JOURNAL, 295(6590), 78-80 [10.1136/bmj.295.6590.78].
Fornasieri, A; Sinico, R; Maldifassi, P; Bernasconi, P; Vegni, M; D'Amico, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140274
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