In order to evaluate functional lymphocyte defects in type II essential mixed cryoglobulinaemia (EMC) in vitro production of immunoglobulins (Ig) and rheumatoid factor (RF) has been studied in basal conditions and under pokeweed mitogen (PWM) stimulation in 15 patients and in 17 control subjects. The major finding was a significantly high basal and inducible production of RF by EMC lymphocytes as compared with the RF production in controls, while synthesis of polyclonal Ig was unaffected. A good correlation existed between in vitro production and serum levels of RF. Peripheral blood SmIg+ and Ia+ cells were also significantly increased. The possibility that EMC shares some pathogenetic mechanism with rheumatoid arthritis on the one hand and with lymphoproliferative diseases on the other is considered.

Sinico, R., Fiorini, G., Fornasieri, A., Bernasconi, P., Benuzzi, S., Paracchini, M., et al. (1986). Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia. ANNALS OF THE RHEUMATIC DISEASES, 45(7), 591-595 [10.1136/ard.45.7.591].

Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia

SINICO, RENATO ALBERTO;
1986

Abstract

In order to evaluate functional lymphocyte defects in type II essential mixed cryoglobulinaemia (EMC) in vitro production of immunoglobulins (Ig) and rheumatoid factor (RF) has been studied in basal conditions and under pokeweed mitogen (PWM) stimulation in 15 patients and in 17 control subjects. The major finding was a significantly high basal and inducible production of RF by EMC lymphocytes as compared with the RF production in controls, while synthesis of polyclonal Ig was unaffected. A good correlation existed between in vitro production and serum levels of RF. Peripheral blood SmIg+ and Ia+ cells were also significantly increased. The possibility that EMC shares some pathogenetic mechanism with rheumatoid arthritis on the one hand and with lymphoproliferative diseases on the other is considered.
Articolo in rivista - Articolo scientifico
Adult; Aged; Cells, Cultured; Cryoglobulinemia; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Lymphocytes; Male; Middle Aged; Pokeweed Mitogens; Rheumatoid Factor
English
591
595
5
Sinico, R., Fiorini, G., Fornasieri, A., Bernasconi, P., Benuzzi, S., Paracchini, M., et al. (1986). Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia. ANNALS OF THE RHEUMATIC DISEASES, 45(7), 591-595 [10.1136/ard.45.7.591].
Sinico, R; Fiorini, G; Fornasieri, A; Bernasconi, P; Benuzzi, S; Paracchini, M; D'Amico, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140264
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