Plasma exchange is increasingly used for management of Essential Mixed Cryoglobulinemia. However little is known about the long term effects of this treatment. Therefore we have reviewed the clinical and laboratory data of 20 patients with type II EMC who were followed for a mean of 24 months. 16 patients had renal involvement, which was characterized histologically in all of them: 9 had diffuse proliferative GN plus endoluminal "thrombi" in 6 and vasculitis in 5, 4 had lobular membranoproliferative GN and 3 had focal proliferative GN. 14 patients had renal failure and 13 had proteinuria greater than or equal to 2 g/24 hr. PE (combined with immunosuppressive drugs in 18) was performed for a mean of 18 procedures. The combined treatment induced prompt remission of extrarenal and renal involvement. Serum creatinine and proteinuria decreased significantly in all but 2 patients during the treatment (s. creatinine from 2.9 to 1.6 mg/dl; proteinuria from 3.5 to 1.6 g/24 hr). Analysis of long term follow up revealed that these effects were long lasting in all the cases. We conclude that PE should be used for EMC nephropathy whenever prompt remission is not obtained by conventional therapy especially in consideration of its long term beneficial effects

Sinico, R., Fornasieri, A., Fiorini, G., Paracchini, M., Renoldi, P., Maldifassi, P., et al. (1985). Plasma exchange in the treatment of essential mixed cryoglobulinemia nephropathy. Long-term follow up. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 8(Suppl 2), 15-18.

Plasma exchange in the treatment of essential mixed cryoglobulinemia nephropathy. Long-term follow up

SINICO, RENATO ALBERTO
Primo
;
1985

Abstract

Plasma exchange is increasingly used for management of Essential Mixed Cryoglobulinemia. However little is known about the long term effects of this treatment. Therefore we have reviewed the clinical and laboratory data of 20 patients with type II EMC who were followed for a mean of 24 months. 16 patients had renal involvement, which was characterized histologically in all of them: 9 had diffuse proliferative GN plus endoluminal "thrombi" in 6 and vasculitis in 5, 4 had lobular membranoproliferative GN and 3 had focal proliferative GN. 14 patients had renal failure and 13 had proteinuria greater than or equal to 2 g/24 hr. PE (combined with immunosuppressive drugs in 18) was performed for a mean of 18 procedures. The combined treatment induced prompt remission of extrarenal and renal involvement. Serum creatinine and proteinuria decreased significantly in all but 2 patients during the treatment (s. creatinine from 2.9 to 1.6 mg/dl; proteinuria from 3.5 to 1.6 g/24 hr). Analysis of long term follow up revealed that these effects were long lasting in all the cases. We conclude that PE should be used for EMC nephropathy whenever prompt remission is not obtained by conventional therapy especially in consideration of its long term beneficial effects
Articolo in rivista - Articolo scientifico
Adult; Creatinine; Cryoglobulinemia; Cryoglobulins; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Proteinuria; Plasma Exchange
English
15
18
4
Sinico, R., Fornasieri, A., Fiorini, G., Paracchini, M., Renoldi, P., Maldifassi, P., et al. (1985). Plasma exchange in the treatment of essential mixed cryoglobulinemia nephropathy. Long-term follow up. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 8(Suppl 2), 15-18.
Sinico, R; Fornasieri, A; Fiorini, G; Paracchini, M; Renoldi, P; Maldifassi, P; Bucci, A; Ferrario, F; D'Amico, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140259
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