T-lymphocyte subsets, using the monoclonal antibodies OKT3 (peripheral T-cells), OKT4 (helper/inducer T-cells) and OKT8 (suppressor/cytotoxic T-cells) were measured in peripheral blood from 110 patients with various forms of primary and secondary glomerulonephritis (GN) (Berger's disease, membranous GN, focal glomerulosclerosis, membranoproliferative GN, lupus nephritis and mixed essential cryoglobulinaemia with GN). We have found a significantly higher OKT4+/OKT8+ ratio in patients with Berger's disease and membranous GN and a rather low OKT4+/OKT8+ ratio in patients with lupus nephritis and mixed essential cryoglobulinaemia, due to a significant decrease in OKT4+ cells. Our results suggest an imbalance in immunoregulatory mechanisms in some forms of GN

Fornasieri, A., Sinico, R., Fiorini, G., Goldaniga, D., Colasanti, G., Vendemia, F., et al. (1983). T-lymphocyte subsets in primary and secondary glomerulonephritis. PROCEEDINGS OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION, 19, 635-641.

T-lymphocyte subsets in primary and secondary glomerulonephritis

SINICO, RENATO ALBERTO
Secondo
;
1983

Abstract

T-lymphocyte subsets, using the monoclonal antibodies OKT3 (peripheral T-cells), OKT4 (helper/inducer T-cells) and OKT8 (suppressor/cytotoxic T-cells) were measured in peripheral blood from 110 patients with various forms of primary and secondary glomerulonephritis (GN) (Berger's disease, membranous GN, focal glomerulosclerosis, membranoproliferative GN, lupus nephritis and mixed essential cryoglobulinaemia with GN). We have found a significantly higher OKT4+/OKT8+ ratio in patients with Berger's disease and membranous GN and a rather low OKT4+/OKT8+ ratio in patients with lupus nephritis and mixed essential cryoglobulinaemia, due to a significant decrease in OKT4+ cells. Our results suggest an imbalance in immunoregulatory mechanisms in some forms of GN
No
Articolo in rivista - Articolo scientifico
Scientifica
Adolescent; Adult; Aged; Antibodies, Monoclonal; Child; Cryoglobulinemia; Female; Glomerulonephritis; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; T-Lymphocytes; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory
English
635
641
7
Fornasieri, A., Sinico, R., Fiorini, G., Goldaniga, D., Colasanti, G., Vendemia, F., et al. (1983). T-lymphocyte subsets in primary and secondary glomerulonephritis. PROCEEDINGS OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION, 19, 635-641.
Fornasieri, A; Sinico, R; Fiorini, G; Goldaniga, D; Colasanti, G; Vendemia, F; Gibelli, A; D'Amico, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/140247
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