Aim: Scanty information is available about the association of isolated daytime hypertension (IDH) and isolated nighttime hypertension (INH) with subclinical cardiac damage in the general population. We examined this issue in patients enrolled in the Pressioni Arteriose Monitorate E Loro Associazioni study. Methods: The analysis included 2021 participants with valid ambulatory blood pressure (BP) monitoring at baseline evaluation. IDH and INH were defined according to current guidelines. Subclinical organ damage was assessed by validated electrocardiographic and echocardiographic criteria. Results: A total of 1258 patients (62.3%) had daytime/night-time normotension, 376 (18.6%) daytime/nighttime hypertension, 231 (11.4%) INH and 156 (7.7%) IDH, respectively. Participants with hypertension, compared with their normotensive counterparts were older, included a higher fraction of men, had higher BMI, LDL cholesterol, triglyceride and glucose levels and exhibited a greater subclinical cardiac involvement. Furthermore, INH and IDH patients showed a similar degree of cardiac damage (i.e. left ventricular mass index: 89 ±18 vs 90±20g/m2), intermediate between normotensive (82±19g/m2) and day-night hypertensive patients (99±24g/m2). Conclusion: The present study shows that IDH and INH exert similar detrimental effects on cardiac structure. In a practical perspective, appropriate antihypertensive chrono-therapeutic approaches in these opposite ambulatory hypertensive subtypes may have important implications in cardiovascular prevention.

Cuspidi, C., Facchetti, R., Bombelli, M., Sala, C., Tadic, M., Grassi, G., et al. (2017). Is night-time hypertension worse than daytime hypertension? A study on cardiac damage in a general population: The PAMELA study. JOURNAL OF HYPERTENSION, 35(3), 506-512 [10.1097/HJH.0000000000001193].

Is night-time hypertension worse than daytime hypertension? A study on cardiac damage in a general population: The PAMELA study

CUSPIDI, CESARE
Primo
;
FACCHETTI, RITA LUCIA
Secondo
;
BOMBELLI, MICHELE;GRASSI, GUIDO
Penultimo
;
MANCIA, GIUSEPPE
Ultimo
2017

Abstract

Aim: Scanty information is available about the association of isolated daytime hypertension (IDH) and isolated nighttime hypertension (INH) with subclinical cardiac damage in the general population. We examined this issue in patients enrolled in the Pressioni Arteriose Monitorate E Loro Associazioni study. Methods: The analysis included 2021 participants with valid ambulatory blood pressure (BP) monitoring at baseline evaluation. IDH and INH were defined according to current guidelines. Subclinical organ damage was assessed by validated electrocardiographic and echocardiographic criteria. Results: A total of 1258 patients (62.3%) had daytime/night-time normotension, 376 (18.6%) daytime/nighttime hypertension, 231 (11.4%) INH and 156 (7.7%) IDH, respectively. Participants with hypertension, compared with their normotensive counterparts were older, included a higher fraction of men, had higher BMI, LDL cholesterol, triglyceride and glucose levels and exhibited a greater subclinical cardiac involvement. Furthermore, INH and IDH patients showed a similar degree of cardiac damage (i.e. left ventricular mass index: 89 ±18 vs 90±20g/m2), intermediate between normotensive (82±19g/m2) and day-night hypertensive patients (99±24g/m2). Conclusion: The present study shows that IDH and INH exert similar detrimental effects on cardiac structure. In a practical perspective, appropriate antihypertensive chrono-therapeutic approaches in these opposite ambulatory hypertensive subtypes may have important implications in cardiovascular prevention.
Articolo in rivista - Articolo scientifico
Cardiac organ damage; General population; Isolated day-time; Isolated night-time hypertension;
night-time hypertension and daytime hypertension
English
2017
35
3
506
512
reserved
Cuspidi, C., Facchetti, R., Bombelli, M., Sala, C., Tadic, M., Grassi, G., et al. (2017). Is night-time hypertension worse than daytime hypertension? A study on cardiac damage in a general population: The PAMELA study. JOURNAL OF HYPERTENSION, 35(3), 506-512 [10.1097/HJH.0000000000001193].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/139938
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