In order to clarify if "idiopathic" RPGN still exists as a distinct entity we reviewed 41 patients with histological picture of diffuse crescentic GN (60% of crescents) and no clinical evidence of systemic disease. According to the presence or absence of intraglomerular necrotizing lesions we subdivided the patients into two different morphological groups: Group I (25 pts) with necrotizing GN and massive periglomerular infiltrates; Group II (16 pts) with intra-extracapillary proliferation and no interstitial infiltrates. Our data suggest that "idiopathic" RPGN does not exist as a distinct entity, but is an expression either of renal limited vasculitis or crescentic GN complicating primary proliferative GN
Ferrario, F., Tadros, M., Napodano, P., Giordano, A., Sinico, R., Fellin, G., et al. (1993). Rapidly progressive glomerulonephritis (RPGN): is there still an "idiopathic" subgroup?. In ANCA-ASSOCIATED VASCULITIDES: IMMUNOLOGICAL AND CLINICAL ASPECTS (pp.431-434). Springer New York LLC [10.1007/978-1-4757-9182-2_76].
Rapidly progressive glomerulonephritis (RPGN): is there still an "idiopathic" subgroup?
SINICO, RENATO ALBERTO;
1993
Abstract
In order to clarify if "idiopathic" RPGN still exists as a distinct entity we reviewed 41 patients with histological picture of diffuse crescentic GN (60% of crescents) and no clinical evidence of systemic disease. According to the presence or absence of intraglomerular necrotizing lesions we subdivided the patients into two different morphological groups: Group I (25 pts) with necrotizing GN and massive periglomerular infiltrates; Group II (16 pts) with intra-extracapillary proliferation and no interstitial infiltrates. Our data suggest that "idiopathic" RPGN does not exist as a distinct entity, but is an expression either of renal limited vasculitis or crescentic GN complicating primary proliferative GN
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