Background: The aim of this study was to evaluate a) the role of bactericidal/permeability-increasing protein (BPI) as a possible antigen determining perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) reactivity in ulcerative colitis and b) the prevalence and clinical correlates of anti-BPI antibodies in patients with ulcerative colitis on the basis of their p-ANCA status. Methods: p-ANCA and anti-BPI antibodies were evaluated by means of indirect immunofluorescence and enzyme-linked immunosorbent assay methods in a group of 112 ulcerative colitis patients (including 42 patients subjected to proctocolectomy) well defined as far as their clinical features and p-ANCA status. Results: Anti-BPI antibodies were detected in 24% of non-operated patients and were significantly more frequent in p-ANCA-positive patients (32% versus 5% in p-ANCA-negative patients; P < 0.015). The prevalence of anti-BPI antibodies was similar in non-operated and operated patients and was high in men, in patients with an extensive and aggressive disease, and in patients developing pouchitis after surgery. Conclusions: These data indicate that BPI is a neutrophil antigen frequently recognized by p-ANCA-positive ulcerative colitis sera. The presence of anti- BPI antibodies appears to identify further immunologic and clinical heterogeneity in ulcerative colitis

Vecchi, M., Sinico, R., Bianchi, M., Radice, A., Gionchetti, P., Campieri, M., et al. (1998). Recognition of bactericidal/permeability-increasing protein by perinuclear anti-neutrophil cytoplasmic antibody-positive sera from ulcerative colitis patients: prevalence and clinical significance. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 33(12), 1284-1288.

Recognition of bactericidal/permeability-increasing protein by perinuclear anti-neutrophil cytoplasmic antibody-positive sera from ulcerative colitis patients: prevalence and clinical significance

SINICO, RENATO ALBERTO
Secondo
;
1998

Abstract

Background: The aim of this study was to evaluate a) the role of bactericidal/permeability-increasing protein (BPI) as a possible antigen determining perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) reactivity in ulcerative colitis and b) the prevalence and clinical correlates of anti-BPI antibodies in patients with ulcerative colitis on the basis of their p-ANCA status. Methods: p-ANCA and anti-BPI antibodies were evaluated by means of indirect immunofluorescence and enzyme-linked immunosorbent assay methods in a group of 112 ulcerative colitis patients (including 42 patients subjected to proctocolectomy) well defined as far as their clinical features and p-ANCA status. Results: Anti-BPI antibodies were detected in 24% of non-operated patients and were significantly more frequent in p-ANCA-positive patients (32% versus 5% in p-ANCA-negative patients; P < 0.015). The prevalence of anti-BPI antibodies was similar in non-operated and operated patients and was high in men, in patients with an extensive and aggressive disease, and in patients developing pouchitis after surgery. Conclusions: These data indicate that BPI is a neutrophil antigen frequently recognized by p-ANCA-positive ulcerative colitis sera. The presence of anti- BPI antibodies appears to identify further immunologic and clinical heterogeneity in ulcerative colitis
Articolo in rivista - Articolo scientifico
Adolescent; Adult; Aged; Antibodies, Antineutrophil Cytoplasmic; Antimicrobial Cationic Peptides; Blood Bactericidal Activity; Blood Proteins; Child; Colitis, Ulcerative; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Male; Middle Aged; Membrane Proteins
English
1284
1288
5
Vecchi, M., Sinico, R., Bianchi, M., Radice, A., Gionchetti, P., Campieri, M., et al. (1998). Recognition of bactericidal/permeability-increasing protein by perinuclear anti-neutrophil cytoplasmic antibody-positive sera from ulcerative colitis patients: prevalence and clinical significance. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 33(12), 1284-1288.
Vecchi, M; Sinico, R; Bianchi, M; Radice, A; Gionchetti, P; Campieri, M; de Franchis, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/139452
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